| Online-Ressource |
Verfasst von: | Busch, Volker [VerfasserIn]  |
| Zeman, Florian [VerfasserIn]  |
| Heckel, Andreas [VerfasserIn]  |
| Menne, Felix [VerfasserIn]  |
| Ellrich, Jens [VerfasserIn]  |
| Eichhammer, Peter [VerfasserIn]  |
Titel: | The effect of transcutaneous vagus nerve stimulation on pain perception |
Titelzusatz: | an experimental study |
Verf.angabe: | Volker Busch, Florian Zeman, Andreas Heckel, Felix Menne, Jens Ellrich, Peter Eichhammer |
Jahr: | 2013 |
Jahr des Originals: | 2012 |
Umfang: | 8 S. |
Fussnoten: | Available online: 22 May 2012 ; Gesehen am 11.12.2020 |
Titel Quelle: | Enthalten in: Brain stimulation |
Ort Quelle: | New York, NY [u.a.] : Elsevier, 2008 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 6(2013), 2, Seite 202-209 |
ISSN Quelle: | 1876-4754 |
Abstract: | Background - Recent preclinical work strongly suggests that vagus nerve stimulation efficiently modulates nociception and pain processing in humans. Most recently, a medical device has offered a transcutaneous electrical stimulation of the auricular branch of the vagus nerve (t-VNS) without any surgery. - Objective - Our study investigates whether t-VNS may have the potential to alter pain processing using a controlled design. - Methods - Different submodalities of the somatosensory system were assessed with quantitative sensory testing (QST) including a tonic heat pain paradigm in 48 healthy volunteers. Each subject participated in two experimental sessions with active t-VNS (stimulation) or sham t-VNS (no stimulation) on different days in a randomized order (crossed-over). One session consisted of two QST measurements on the ipsi- and contralateral hand, each before and during 1 h of a continuous t-VNS on the left ear using rectangular pulses (250 μS, 25 Hz). - Results - We found an increase of mechanical and pressure pain threshold and a reduction of mechanical pain sensitivity. Moreover, active t-VNS significantly reduced pain ratings during sustained application of painful heat for 5 min compared to sham condition. No relevant alterations of cardiac or breathing activity or clinical relevant side effects were observed during t-VNS. - Conclusions - Our findings of a reduced sensitivity of mechanically evoked pain and an inhibition of temporal summation of noxious tonic heat in healthy volunteers may pave the way for future studies on patients with chronic pain addressing the potential analgesic effects of t-VNS under clinical conditions. |
DOI: | doi:10.1016/j.brs.2012.04.006 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.brs.2012.04.006 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S1935861X12000708 |
| DOI: https://doi.org/10.1016/j.brs.2012.04.006 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Analgesia |
| Autonomic nervous system |
| Neuromodulation |
| Pain thresholds |
| Quantitative sensory testing |
K10plus-PPN: | 1742602630 |
Verknüpfungen: | → Zeitschrift |
¬The¬ effect of transcutaneous vagus nerve stimulation on pain perception / Busch, Volker [VerfasserIn]; 2013 (Online-Ressource)