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Verfasst von:Kopp, Benedikt [VerfasserIn]   i
 Jensen, Maria Fuglsang [VerfasserIn]   i
 Mein, Stewart [VerfasserIn]   i
 Hoffmann, Lone [VerfasserIn]   i
 Nyström, Håkan [VerfasserIn]   i
 Falk, Marianne [VerfasserIn]   i
 Haberer, Thomas [VerfasserIn]   i
 Abdollahi, Amir [VerfasserIn]   i
 Debus, Jürgen [VerfasserIn]   i
 Mairani, Andrea [VerfasserIn]   i
Titel:FRoG: an independent dose and LETd prediction tool for proton therapy at ProBeam® facilities
Verf.angabe:Benedikt Kopp, Maria Fuglsang Jensen, Stewart Mein, Lone Hoffmann, Håkan Nyström, Marianne Falk, Thomas Haberer, Amir Abdollahi, Jürgen Debus, Andrea Mairani
E-Jahr:2020
Jahr:31 July 2020
Umfang:13 S.
Fussnoten:Gesehen am 15.01.2020 ; Im Titel ist der Buchstabe "d" nach LET tiefgestellt ; Im Titel ist das Registered-Symbol hochgestellt
Titel Quelle:Enthalten in: Medical physics
Ort Quelle:Hoboken, NJ : Wiley, 1974
Jahr Quelle:2020
Band/Heft Quelle:47(2020), 10, Seite 5274-5286
ISSN Quelle:2473-4209
 1522-8541
Abstract:Purpose Particle therapy is becoming increasingly available world-wide for precise tumor targeting, its favorable depth dose deposition, and increased biological damage to tumor tissue compared to conventional photon therapy. As demand increases for improved robustness and conformality, next-generation secondary dose calculation engines are needed to verify treatment plans independently and provide estimates for clinical decision-making factors, such as dose-averaged linear energy transfer (LETd) and relative biological effectiveness (RBE). Method FRoG (Fast dose Recalculation on GPU) has been installed and commissioned at the Danish Centre for Particle Therapy (DCPT). FRoG was developed for synchrotron-based facilities and has previously demonstrated good agreement with gold-standard Monte Carlo simulations and measurements. In this work, additions and modifications to FRoG’s pencil beam algorithm to support the ion beam delivery with cyclotron-based technology as used at the DCPT, range shifter (RS) implementation, and robustness analysis methods are presented. FRoG dose predictions are compared to measurements and predictions of the clinical treatment planning system (TPS) Eclipse (Varian Medical Systems, Palo Alto, United States of America, CA, v.13.7.16) in both homogenous and heterogeneous scenarios using a solid-water/water and a half-head anthropomorphic phantom, respectively. Additional capabilities of FRoG are explored by performing a plan robustness analysis, analyzing dose and LETd for ten patients. Results Mid-target measurements in spread-out Bragg Peaks (SOBP) were on average within −0.19% ± 0.30% and ≤0.5% of FRoG predictions for irradiations without and with RS, respectively. Average 3%/2mm 3D γ-analysis passing rates were 99.1% for 200 patient plan QA comparisons. Measurement with an anthropomorphic head-phantom yielded a γ-passing rate >98%. Overall, maximum target differences in D02% of <2% between the TPS and FRoG were observed for patient plans. The robustness analysis study accounting for range, delivery, and positioning uncertainties revealed small differences in target dose and a maximum LETdVH02% (LETd received by 2% of the volume having dose larger than 1% of maximum dose) values below 10.1 keV/µm to the brain stem. Conclusion We demonstrate that auxiliary dose calculation systems like FRoG can yield excellent agreement to measurements comparable to clinical beam models. Through this work, application of FRoG as a secondary engine at third party cyclotron-based particle treatment facilities is now established for dose verification as well as providing further insight on LETd and variable RBE distributions for protons, currently absent from the standard clinical TPS.
DOI:doi:10.1002/mp.14417
URL:kostenfrei: Volltext: https://doi.org/https://doi.org/10.1002/mp.14417
 kostenfrei: Volltext: https://aapm.onlinelibrary.wiley.com/doi/abs/10.1002/mp.14417
 DOI: https://doi.org/10.1002/mp.14417
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:FRoG
 independent dose engine
 ion-beam therapy
 LETd
 robustness analysis
K10plus-PPN:1744763291
Verknüpfungen:→ Zeitschrift
 
 
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