Is frontal lobe involved in the generation of auditory evoked P50?

• Verfasst von: Weißer, Regina [VerfasserIn]
• Verfasst von: Weisbrod, Matthias [VerfasserIn]
• Verfasst von: Röhrig, Miriam [VerfasserIn]
• Verfasst von: Rupp, André [VerfasserIn]
• Verfasst von: Schröder, Johannes [VerfasserIn]
• Verfasst von: Scherg, Michael [VerfasserIn]
• Titel: Is frontal lobe involved in the generation of auditory evoked P50?
• Verf.angabe: Regina Weisser, Matthias Weisbrod, Miriam Roehrig, André Rupp, Johannes Schroeder, Michael Scherg
• Jahr: 2001
• Umfang: 5 S.
• Fussnoten: Gesehen am 19.01.2021
• Titel Quelle: Enthalten in: Neuroreport
• Ort Quelle: London : Lippincott Williams & Wilkins, 1990
• Jahr Quelle: 2001
• Band/Heft Quelle: 12(2001), 15, Seite 3303-3307
• ISSN Quelle: 1473-558X
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1744978697

Abstract

This study examined the functional substrate of P50 suppression. Auditory evoked potentials (AEPs) and magnetic fields (AEFs) were recorded from healthy subjects simultaneously and analyzed using spatio-temporal source analysis. The resulting equivalent dipole model for the AEP consisted of one source in the auditory cortex (AC) of each hemisphere and an radially oriented medial frontal source, both with maximum AEP activity around 50 ms. The frontal source was functionally separated from the AC sources since it peaked significantly later and showed significantly larger P50 amplitude suppression. P30m showed neither suppression nor substantial frontal activity. In sum, this study relates P50 suppression to reduction of AC source activity and is the first to yield direct evidence for frontal involvement in P50 suppression.