Actin cytoskeletal dynamics in T lymphocyte activation and migration

• Verfasst von: Samstag, Yvonne [VerfasserIn]
• Verfasst von: Eibert, Sybille M. [VerfasserIn]
• Verfasst von: Klemke, Martin [VerfasserIn]
• Verfasst von: Wabnitz, Guido H. [VerfasserIn]
• Titel: Actin cytoskeletal dynamics in T lymphocyte activation and migration
• Verf.angabe: Yvonne Samstag, Sybille M. Eibert, Martin Klemke, Guido H. Wabnitz
• E-Jahr: 2003
• Jahr: 01 January 2003
• Umfang: 19 S.
• Fussnoten: Gesehen am 22.02.2021
• Titel Quelle: Enthalten in: Journal of leukocyte biology
• Ort Quelle: Hoboken, NJ : Wiley, 1984
• Jahr Quelle: 2003
• Band/Heft Quelle: 73(2003), 1, Seite 30-48
• ISSN Quelle: 1938-3673
• DOI: doi:10.1189/jlb.0602272
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Actins
• Sach-SW: Animals
• Sach-SW: Cell Polarity
• Sach-SW: Chemotaxis, Leukocyte
• Sach-SW: Cytoskeleton
• Sach-SW: Humans
• Sach-SW: Lymphocyte Activation
• Sach-SW: Signal Transduction
• Sach-SW: T-Lymphocytes
• K10plus-PPN: 1749068729

Abstract

Dynamic rearrangements of the actin cytoskeleton are crucial for the function of numerous cellular elements including T lymphocytes. They are required for migration of T lymphocytes through the body to scan for the presence of antigens, as well as for the formation and stabilization of the immunological synapse at the interface between antigen-presenting cells and T lymphocytes. Supramolecular activation clusters within the immunological synapse play an important role for the initiation of T cell responses and for the execution of T cell effector functions. In addition to the T cell receptor/CD3 induced actin nucleation via Wasp/Arp2/3-activation, signals through accessory receptors of the T cell (i.e., costimulation) regulate actin cytoskeletal dynamics. In this regard, the actin-binding proteins cofilin and L-plastin represent prominent candidates linking accessory receptor stimulation to the rearrangement of the actin cytoskeleton. Cofilin enhances actin polymerization via its actin-severing activity, and as a long-lasting effect, cofilin generates novel actin monomers through F-actin depolymerization. L-plastin stabilizes actin filament structures by means of its actin-bundling activity.