| |  Online-Ressource |
|---|
| Verfasst von: | Möller, Marcus Johannes [VerfasserIn]  |
|---|
| | Soofi, Abdulsalam [VerfasserIn] |
|---|
| | Braun, Gerald S. [VerfasserIn] |
|---|
| | Li, Xiaodong [VerfasserIn] |
|---|
| | Watzl, Carsten [VerfasserIn] |
|---|
| | Kriz, Wilhelm [VerfasserIn] |
|---|
| | Holzman, Lawrence B. [VerfasserIn] |
|---|
| Titel: | Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization |
|---|
| Verf.angabe: | Marcus J. Moeller, Abdulsalam Soofi, Gerald S. Braun, Xiaodong Li, Carsten Watzl, Wilhelm Kriz and Lawrence B. Holzman |
|---|
| Jahr: | 2004 |
|---|
| Umfang: | 11 S. |
|---|
| Teil: | volume:23 |
|---|
| | year:2004 |
|---|
| | number:19 |
|---|
| | pages:3769-3779 |
|---|
| | extent:11 |
|---|
| Fussnoten: | Gesehen am 01.03.2021 |
|---|
| Titel Quelle: | Enthalten in: European Molecular Biology OrganizationThe EMBO journal |
|---|
| Ort Quelle: | Heidelberg : EMBO Press, 1982 |
|---|
| Jahr Quelle: | 2004 |
|---|
| Band/Heft Quelle: | 23(2004), 19, Seite 3769-3779 |
|---|
| ISSN Quelle: | 1460-2075 |
|---|
| Abstract: | Cell migration requires integration of cellular processes resulting in cell polarization and actin dynamics. Previous work using tools of Drosophila genetics suggested that protocadherin fat serves in a pathway necessary for determining cell polarity in the plane of a tissue. Here we identify mammalian FAT1 as a proximal element of a signaling pathway that determines both cellular polarity in the plane of the monolayer and directed actin-dependent cell motility. FAT1 is localized to the leading edge of lamellipodia, filopodia, and microspike tips where FAT1 directly interacts with Ena/VASP proteins that regulate the actin polymerization complex. When targeted to mitochondrial outer leaflets, FAT1 cytoplasmic domain recruits components of the actin polymerization machinery sufficient to induce ectopic actin polymerization. In an epithelial cell wound model, FAT1 knockdown decreased recruitment of endogenous VASP to the leading edge and resulted in impairment of lamellipodial dynamics, failure of polarization, and an attenuation of cell migration. FAT1 may play an integrative role regulating cell migration by participating in Ena/VASP-dependent regulation of cytoskeletal dynamics at the leading edge and by transducing an Ena/VASP-independent polarity cue. |
|---|
| DOI: | doi:10.1038/sj.emboj.7600380 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/sj.emboj.7600380 |
|---|
| | Volltext: https://www.embopress.org/doi/full/10.1038/sj.emboj.7600380 |
|---|
| | DOI: https://doi.org/10.1038/sj.emboj.7600380 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Actins |
|---|
| | Animals |
|---|
| | Cadherins |
|---|
| | Cell Adhesion Molecules |
|---|
| | Cell Movement |
|---|
| | Cell Polarity |
|---|
| | Cytoskeleton |
|---|
| | Genes, Tumor Suppressor |
|---|
| | Humans |
|---|
| | Immunoglobulin G |
|---|
| | Mice |
|---|
| | Pseudopodia |
|---|
| | Rabbits |
|---|
| | RNA, Small Interfering |
|---|
| | Wound Healing |
|---|
| K10plus-PPN: | 1750013150 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Protocadherin FAT1 binds Ena/VASP proteins and is necessary for actin dynamics and cell polarization / Möller, Marcus Johannes [VerfasserIn]; 2004 (Online-Ressource)
