Status: Bibliographieeintrag
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| Verfasst von: | Feng, Weijun [VerfasserIn]  |
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| | Khan, Muhammad Amir [VerfasserIn] |
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| | Bellvís Zambrano, Pablo [VerfasserIn] |
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| | Zhu, Zhe [VerfasserIn] |
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| | Bernhardt, Olga [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Liu, Hai-Kun [VerfasserIn] |
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| Titel: | The chromatin remodeler CHD7 regulates adult neurogenesis via activation of SoxC transcription factors |
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| Verf.angabe: | Weijun Feng, Muhammad Amir Khan, Pablo Bellvis, Zhe Zhu, Olga Bernhardt, Christel Herold-Mende, and Hai-Kun Liu |
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| E-Jahr: | 2013 |
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| Jahr: | 3 July 2013 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 12.03.2021 |
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| Titel Quelle: | Enthalten in: Cell stem cell |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 13(2013), 1, Seite 62-72 |
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| ISSN Quelle: | 1875-9777 |
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| Abstract: | Chromatin factors that regulate neurogenesis in the central nervous system remain to be explored. Here, we demonstrate that the chromatin remodeler chromodomain-helicase-DNA-binding protein 7 (CHD7), a protein frequently mutated in human CHARGE syndrome, is a master regulator of neurogenesis in mammalian brain. CHD7 is selectively expressed in actively dividing neural stem cells (NSCs) and progenitors. Genetic inactivation of CHD7 in NSCs leads to a reduction of neuronal differentiation and aberrant dendritic development of newborn neurons. Strikingly, physical exercise can rescue the CHD7 mutant phenotype in the adult hippocampal dentate gyrus. We further show that in NSCs, CHD7 stimulates the expression of Sox4 and Sox11 genes via remodeling their promoters to an open chromatin state. Our study demonstrates an essential role of CHD7 in activation of the neuronal differentiation program in NSCs, thus providing insights into epigenetic regulation of stem cell differentiation and molecular mechanism of human CHARGE syndrome. |
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| DOI: | doi:10.1016/j.stem.2013.05.002 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.stem.2013.05.002 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1934590913001951 |
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| | DOI: https://doi.org/10.1016/j.stem.2013.05.002 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1751222144 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ chromatin remodeler CHD7 regulates adult neurogenesis via activation of SoxC transcription factors / Feng, Weijun [VerfasserIn]; 3 July 2013 (Online-Ressource)
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