NF-κB is activated and promotes cell death in focal cerebral ischemia

• Verfasst von: Schneider, Armin [VerfasserIn]
• Verfasst von: Martín-Villalba, Ana [VerfasserIn]
• Verfasst von: Weih, Falk [VerfasserIn]
• Verfasst von: Vogel, Johannes [VerfasserIn]
• Verfasst von: Wirth, Thomas [VerfasserIn]
• Verfasst von: Schwaninger, Markus [VerfasserIn]
• Titel: NF-κB is activated and promotes cell death in focal cerebral ischemia
• Verf.angabe: Armin Schneider, Ana Martin-Villalba, Falk Weih, Johannes Vogel, Thomas Wirth & Markus Schwaninger
• Jahr: 1999
• Umfang: 6 S.
• Teil: volume:5
• Teil: year:1999
• Teil: number:5
• Teil: pages:554-559
• Teil: extent:6
• Fussnoten: Gesehen am 01.04.2021
• Titel Quelle: Enthalten in: Nature medicine
• Ort Quelle: New York, NY : Nature America Inc., 1995
• Jahr Quelle: 1999
• Band/Heft Quelle: 5(1999), 5, Seite 554-559
• ISSN Quelle: 1546-170X
• DOI: doi:10.1038/8432
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1753064309

Abstract

The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-κB was activated, as determined by increased expression of an NF-κB-driven reporter transgene, nuclear translocation of NF-κB in neurons and enhanced DNA binding of NF-κB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death-promoting role of NF-κB in focal ischemia. NF-κB may provide a new pharmacological target in neurologic disease.