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| Verfasst von: | Porubský, Štefan [VerfasserIn]  |
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| | Popovic, Zoran V. [VerfasserIn] |
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| | Badve, Sunil [VerfasserIn] |
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| | Banz, Yara [VerfasserIn] |
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| | Berezowska, Sabina [VerfasserIn] |
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| | Borchert, Dietmar [VerfasserIn] |
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| | Brüggemann, Monika [VerfasserIn] |
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| | Gaiser, Timo [VerfasserIn] |
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| | Graeter, Thomas [VerfasserIn] |
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| | Hollaus, Peter [VerfasserIn] |
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| | Huettl, Katrin S. [VerfasserIn] |
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| | Kotrova, Michaela [VerfasserIn] |
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| | Kreft, Andreas [VerfasserIn] |
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| | Kugler, Christian [VerfasserIn] |
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| | Lötscher, Fabian [VerfasserIn] |
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| | Möller, Burkhard [VerfasserIn] |
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| | Ott, German [VerfasserIn] |
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| | Preißler, Gerhard [VerfasserIn] |
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| | Rößner, Eric [VerfasserIn] |
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| | Rosenwald, Andreas [VerfasserIn] |
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| | Ströbel, Philipp [VerfasserIn] |
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| | Marx, Alexander [VerfasserIn] |
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| Titel: | Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features |
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| Titelzusatz: | Strong association with lymphomas and non-myasthenic autoimmune diseases |
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| Verf.angabe: | Stefan Porubsky, Zoran V. Popovic, Sunil Badve, Yara Banz, Sabina Berezowska, Dietmar Borchert, Monika Brüggemann, Timo Gaiser, Thomas Graeter, Peter Hollaus, Katrin S. Huettl, Michaela Kotrova, Andreas Kreft, Christian Kugler, Fabian Lötscher, Burkhard Möller, German Ott, Gerhard Preissler, Eric Roessner, Andreas Rosenwald, Philipp Ströbel and Alexander Marx |
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| E-Jahr: | 2021 |
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| Jahr: | 16 January 2021 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 04.05.2021 |
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| Titel Quelle: | Enthalten in: Cancers |
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| Ort Quelle: | Basel : MDPI, 2009 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 13(2021), 2, Artikel-ID 315, Seite 1-13 |
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| ISSN Quelle: | 2072-6694 |
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| Abstract: | Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32–80; lesion diameter 7.0 cm, 1–14.5; median, range), five (14%) showed associated lymphomas, including four (11%) thymic MALT lymphomas and one (3%) diffuse large B-cell lymphoma. One additional case showed a clonal B-cell-receptor rearrangement without evidence of lymphoma. Twelve (33%) patients (7 women) suffered from partially overlapping autoimmune diseases: systemic lupus erythematosus (n = 4, 11%), rheumatoid arthritis (n = 3, 8%), myasthenia gravis (n = 2, 6%), asthma (n = 2, 6%), scleroderma, Sjögren syndrome, pure red cell aplasia, Grave’s disease and anti-IgLON5 syndrome (each n = 1, 3%). Among 11 primary thymic MALT lymphomas, remnants of LESA-like TH were found in two cases (18%). In summary, LESA-like TH shows a striking association with autoimmunity and predisposes to lymphomas. Thus, a hematologic and rheumatologic workup should become standard in patients diagnosed with LESA-like TH. Radiologists and clinicians should be aware of LESA-like TH as a differential diagnosis for mediastinal mass lesions in patients with autoimmune diseases. |
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| DOI: | doi:10.3390/cancers13020315 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/cancers13020315 |
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| | Volltext: https://www.mdpi.com/2072-6694/13/2/315 |
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| | DOI: https://doi.org/10.3390/cancers13020315 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | autoimmune disease |
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| | imaging |
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| | LESA |
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| | lymphoma |
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| | myasthenia |
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| | pathology |
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| | surgery |
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| | thymic epithelial tumor |
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| | thymitis |
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| | thymus |
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| K10plus-PPN: | 1757086692 |
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| Verknüpfungen: | → Zeitschrift |
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Thymic hyperplasia with lymphoepithelial sialadenitis (LESA)-like features / Porubský, Štefan [VerfasserIn]; 16 January 2021 (Online-Ressource)
