Efficacy of sonothrombolysis in a rat model of embolic ischemic stroke

• Verfasst von: Daffertshofer, Michael [VerfasserIn]
• Verfasst von: Huang, Z. [VerfasserIn]
• Verfasst von: Fatar, Marc [VerfasserIn]
• Verfasst von: Popolo, M. [VerfasserIn]
• Verfasst von: Schröck, Helmut [VerfasserIn]
• Verfasst von: Kuschinsky, Wolfgang [VerfasserIn]
• Verfasst von: Moskowitz, M. A. [VerfasserIn]
• Verfasst von: Hennerici, Michael G. [VerfasserIn]
• Titel: Efficacy of sonothrombolysis in a rat model of embolic ischemic stroke
• Verf.angabe: M. Daffertshofer, Z. Huang, M. Fatar, M. Popolo, H. Schroeck, W. Kuschinsky, M.A. Moskowitz, M.G. Hennerici
• E-Jahr: 2004
• Jahr: 15 April 2004
• Umfang: 5 S.
• Fussnoten: Gesehen am 05.05.2021
• Titel Quelle: Enthalten in: Neuroscience letters
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1975
• Jahr Quelle: 2004
• Band/Heft Quelle: 361(2004), 1, Seite 115-119
• ISSN Quelle: 1872-7972
• DOI: doi:10.1016/j.neulet.2004.02.003
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Rats
• Sach-SW: Stroke
• Sach-SW: Thrombolysis
• Sach-SW: Ultrasound
• K10plus-PPN: 1757118721

Abstract

The key goal in the treatment of acute ischemic stroke is fast vessel recanalization. Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is efficient in humans but mean time for recanalization is within hours. Ultrasound bio-effects has been shown to facilitate rt-PA mediated thrombolysis in peripheral arteries. We used an embolic stroke model in the rat. In all rats we induced an ischemic stroke by a selective occlusion of the middle cerebral artery with whole blood clots. From an entire collective of 54 rats 47 completed the protocol (n=7 died early). Four different groups (no treatment n=6; full dose rt-PA treatment only [10 mg/kg per body weight] n=14, half dose rt-PA treatment plus ultrasound n=10, and full dose rt-PA treatment plus ultrasound n=17) were investigated. We found a significant reduction of absolute as well as relative infarct volume in the full dose rt-PA plus ultrasound group (81±72 mm3; P<0.05) in comparison to untreated rats (253±159 mm3; P<0.05) as well as in comparison to rats treated with full dose rt-PA only (167±91 mm3; P<0.05). There were five intracranial bleedings giving a bleeding rate of 9.3%. In summary: ultrasound treatment in addition to rt-PA is more effective than single rt-PA treatment in reducing infarct volume and safe with regard to bleeding.