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Verfasst von:Hamann, Gerhard [VerfasserIn]   i
 Schröck, Helmut [VerfasserIn]   i
 Burggraf, Dorothe [VerfasserIn]   i
 Wunderlich, Nathalie [VerfasserIn]   i
 Liebetrau, Martin [VerfasserIn]   i
 Kuschinsky, Wolfgang [VerfasserIn]   i
Titel:Microvascular basal lamina damage after embolic stroke in the rat
Titelzusatz:relationship to cerebral blood flow
Verf.angabe:Gerhard F Hamann, Helmut Schröck, Dorothe Burggraf, Nathalie Wunderlich, Martin Liebetrau, and Wolfgang Kuschinsky
E-Jahr:2003
Jahr:[2003]
Umfang:5 S.
Illustrationen:Illustrationen
Teil:volume:23
 year:2003
 number:11
 pages:1293-1297
 extent:5
Fussnoten:First published November 1, 2003 ; Gesehen am 05.05.2021
Titel Quelle:Enthalten in: Journal of cerebral blood flow & metabolism
Ort Quelle:Thousands Oaks, Calif. : Sage, 1981
Jahr Quelle:2003
Band/Heft Quelle:23(2003), 11, Seite 1293-1297
ISSN Quelle:1559-7016
Abstract:Microvascular basal lamina damage has been demonstrated after balloon occlusion of the middle cerebral artery in the nonhuman primate and after intravascular filament occlusion in the rat. The aim of the present study was to investigate in the rat whether microvascular damage can be found in the stroke model of intracarotid clot injection as early as 3 hours after clot injection and whether microvascular damage relates to the level of regional cerebral blood flow (rCBF). Microvascular densities and total stained microvascular areas were determined by immunohistochemistry of collagen type IV in cortex and basal ganglia and automatic video-imaging analysis. rCBF was measured by autoradiography in the same brain areas. Compared with the corresponding areas in the nonischemic hemisphere, a significant loss of microvascular density (−16%) and total stained microvascular areas (−10%) was observed in these areas. The reduction of microvascular basal lamina staining was comparable in all animals and was not related to the value of rCBF when measured 3 hours after onset of embolic stroke. In conclusion, microvascular damage occurs as soon as 3 hours after intracarotid clot injection, even in brain areas in which rCBF has returned to normal values.
DOI:doi:10.1097/01.WCB.0000090682.07515.5A
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1097/01.WCB.0000090682.07515.5A
 DOI: https://doi.org/10.1097/01.WCB.0000090682.07515.5A
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Autoradiography
 Basal lamina
 Cerebral blood flow
 Cerebral ischemia
 Collagen type IV
 Embolic middle cerebral artery occlusion
 Microvasculature
K10plus-PPN:1757135162
Verknüpfungen:→ Zeitschrift

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