Status: Bibliographieeintrag
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| Verfasst von: | Duelli, Roman [VerfasserIn]  |
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| | Maurer, Martin H. [VerfasserIn] |
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| | Kuschinsky, Wolfgang [VerfasserIn] |
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| Titel: | Decreased glucose transporter densities, rate constants and glucose utilization in visual structures of rat brain during chronic visual deprivation |
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| Verf.angabe: | R. Duelli, M.H. Maurer, W. Kuschinsky (Department of Physiology, University of Heidelberg, Heidelberg, Germany) |
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| E-Jahr: | 1998 |
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| Jahr: | [1998] |
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| Umfang: | 4 S. |
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| Fussnoten: | Gesehen am 28.05.2021 |
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| Titel Quelle: | Enthalten in: Neuroscience letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 1998 |
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| Band/Heft Quelle: | 250(1998), 1, Seite 49-52 |
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| ISSN Quelle: | 1872-7972 |
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| Abstract: | The question was investigated whether local changes in glucose transporter densities and transport kinetics can occur when local cerebral glucose utilization (LCGU) is decreased in some brain structures. Unilateral visual deprivation was induced by monocular enucleation in 25 rats. After 1 week, the contralateral structures of the visual system were analyzed for (1) densities of glucose transporters Glut1 and Glut3 (immunoautoradiography), (2) LCGU (2-[14C]deoxyglucose method) and (3) local rate constants (3-O-[14C]methylglucose method). The ipsilateral structures served as controls. During chronic visual deprivation Glut1 and Glut3 densities, LCGU and rate constants were significantly decreased in some structures of the visual system and remained unchanged in others. These results indicate a moderate degree of downregulation of glucose transporters, LCGU and rate constants in the visual system during visual deprivation. |
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| DOI: | doi:10.1016/S0304-3940(98)00457-1 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/S0304-3940(98)00457-1 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0304394098004571 |
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| | DOI: https://doi.org/10.1016/S0304-3940(98)00457-1 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Autoradiography |
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| | Glut1 |
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| | Glut3 |
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| | Immunostaining |
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| | Local cerebral glucose utilization |
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| K10plus-PPN: | 1759108200 |
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| Verknüpfungen: | → Zeitschrift |
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Decreased glucose transporter densities, rate constants and glucose utilization in visual structures of rat brain during chronic visual deprivation / Duelli, Roman [VerfasserIn]; [1998] (Online-Ressource)
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