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Verfasst von:Wiedmann, Felix Tobias [VerfasserIn]   i
 Schlund, Daniel [VerfasserIn]   i
 Kraft, Manuel [VerfasserIn]   i
 Nietfeld, Jendrik [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 Schmidt, Constanze [VerfasserIn]   i
 Thomas, Dierk [VerfasserIn]   i
Titel:Electrophysiological effects of non-vitamin K antagonist oral anticoagulants on atrial repolarizing potassium channels
Verf.angabe:Felix Wiedmann, Daniel Schlund, Manuel Kraft, Jendrik Nietfeld, Hugo A Katus, Constanze Schmidt, and Dierk Thomas
E-Jahr:2020
Jahr:17 July 2020
Umfang:10 S.
Fussnoten:Gesehen am 21.06.2021
Titel Quelle:Enthalten in: Europace
Ort Quelle:Oxford : Oxford Univ. Press, 1999
Jahr Quelle:2020
Band/Heft Quelle:22(2020), 9, Seite 1409-1418
ISSN Quelle:1532-2092
Abstract:Aims: Non-vitamin K antagonist oral anticoagulants (NOACs) are widely used in the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (AF). The efficacy of NOACs has been attributed in part to pleiotropic effects that are mediated through effects on thrombin, factor Xa, and their respective receptors. Direct pharmacological effects of NOACs and cardiac ion channels have not been addressed to date. We hypothesized that the favourable clinical outcome of NOAC use may be associated with previously unrecognized effects on atrial repolarizing potassium channels. Methods and results: This study was designed to elucidate acute pharmacological effects of NOACs on cloned ion channels Kv11.1, Kv1.5, Kv4.3, Kir2.1, Kir2.2, and K2P2.1 contributing to IKr, IKur, Ito, IK1, and IK2P K+ currents. Human genes, KCNH2, KCNA5, KCND3, KCNJ2, KCNJ12, and KCNK2, were heterologously expressed in Xenopus laevis oocytes, and currents were recorded using voltage-clamp electrophysiology. Apixaban, dabigatran, edoxaban, and rivaroxaban applied at 1 µM did not significantly affect peak current amplitudes of Kv11.1, Kv1.5, Kv4.3, Kir2.1, Kir2.2, or K2P2.1 K+ channels. Furthermore, biophysical characterization did not reveal significant effects of NOACs on current-voltage relationships of study channels. Conclusion: Apixaban, dabigatran, edoxaban, and rivaroxaban did not exhibit direct functional interactions with human atrial K+ channels underlying IKr, IKur, Ito, IK1, and IK2P currents that could account for beneficial clinical outcome associated with the drugs. Indirect or chronic effects and potential underlying signalling mechanisms remain to be investigated.
DOI:doi:10.1093/europace/euaa129
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1093/europace/euaa129
 DOI: https://doi.org/10.1093/europace/euaa129
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1760897841
Verknüpfungen:→ Zeitschrift

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