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| Verfasst von: | Hundemer, Michael [VerfasserIn]  |
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| | Klein, Ulrike [VerfasserIn] |
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| | Hose, Dirk [VerfasserIn] |
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| | Raab, Marc-Steffen [VerfasserIn] |
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| | Cremer, Friedrich Walter [VerfasserIn] |
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| | Jauch, Anna [VerfasserIn] |
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| | Benner, Axel [VerfasserIn] |
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| | Heiß, Christiane [VerfasserIn] |
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| | Moos, Marion [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Goldschmidt, Hartmut [VerfasserIn] |
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| Titel: | Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14) |
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| Verf.angabe: | M. Hundemer, U. Klein, D. Hose, M.-S. Raab, F. W. Cremer, A. Jauch, A. Benner, C. Heiss, M. Moos, A.D. Ho and H. Goldschmidt |
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| E-Jahr: | 2007 |
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| Jahr: | 24 September 2007 |
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| Umfang: | 5 S. |
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| Illustrationen: | Diagramme |
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| Teil: | volume:40 |
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| | year:2007 |
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| | number:11 |
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| | pages:1033-1037 |
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| | extent:5 |
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| Fussnoten: | Gesehen am 20.10.2021 |
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| Titel Quelle: | Enthalten in: Bone marrow transplantation |
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| Ort Quelle: | London : Springer Nature, 1997 |
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| Jahr Quelle: | 2007 |
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| Band/Heft Quelle: | 40(2007), 11, Seite 1033-1037 |
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| ISSN Quelle: | 1476-5365 |
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| Abstract: | Lack of CD56 expression was reported to be associated with a poor prognosis in multiple myeloma (MM) patients treated with conventional chemotherapy. Aim of our retrospective study was to analyse whether CD56 expression on MM cells reveals as a prognostic factor in patients treated with high-dose chemotherapy. MM cells of 99 patients prior to treatment with high-dose chemotherapy were analysed for CD56 expression by flow cytometry. Multivariable analysis of event-free survival in these patients showed no statistically significant difference between the CD56(-) (n=28) and the CD56(+) (n=71) group. The lack of CD56 expression on MM cells of these patients correlated significantly with the presence of translocation (11;14) (t(11;14)) (estimated correlation coefficient=0.655 95%, confidence interval (0.481; 0.779)). In summary, our results indicate that lack of CD56 expression on MM cells is not a prognostic marker in patients treated with high-dose chemotherapy, but is associated with t(11;14). |
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| DOI: | doi:10.1038/sj.bmt.1705857 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/sj.bmt.1705857 |
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| | DOI: https://doi.org/10.1038/sj.bmt.1705857 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Aged |
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| | Biomarkers |
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| | CD56 Antigen |
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| | Chromosomes, Human, Pair 11 |
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| | Chromosomes, Human, Pair 17 |
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| | Disease-Free Survival |
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| | Dose-Response Relationship, Drug |
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| | Female |
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| | Hematopoietic Stem Cell Transplantation |
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| | Humans |
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| | Male |
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| | Melphalan |
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| | Middle Aged |
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| | Multiple Myeloma |
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| | Myeloablative Agonists |
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| | Retrospective Studies |
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| | Translocation, Genetic |
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| | Transplantation, Autologous |
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| K10plus-PPN: | 1774614952 |
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| Verknüpfungen: | → Zeitschrift |
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Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14) / Hundemer, Michael [VerfasserIn]; 24 September 2007 (Online-Ressource)
