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Verfasst von:Seleit, Ali [VerfasserIn]   i
 Groß, Karen [VerfasserIn]   i
 Onistschenko, Jasmin [VerfasserIn]   i
 Hoang, Oi Pui [VerfasserIn]   i
 Theelke, Jonas [VerfasserIn]   i
 Centanin, Lázaro [VerfasserIn]   i
Titel:Local tissue interactions govern pLL patterning in medaka
Verf.angabe:Ali Seleit, Karen Gross, Jasmin Onistschenko, Oi Pui Hoang, Jonas Theelke, Lazaro Centanin
E-Jahr:2022
Jahr:11 September 2021
Umfang:13 S.
Fussnoten:Gesehen am 11.11.2021
Titel Quelle:Enthalten in: Developmental biology
Ort Quelle:Amsterdam [u.a.] : Elsevier, 1959
Jahr Quelle:2022
Band/Heft Quelle:481(2022) vom: Jan., Seite 1-13
ISSN Quelle:1095-564X
Abstract:Vertebrate organs are arranged in a stereotypic, species-specific position along the animal body plan. Substantial morphological variation exists between related species, especially so in the vastly diversified teleost clade. It is still unclear how tissues, organs and systems can accommodate such diverse scaffolds. Here, we use the distinctive arrangement of neuromasts in the posterior lateral line (pLL) system of medaka fish to address the tissueinteractions defining a pattern. We show that patterning in this peripheral nervous system is established by autonomous organ precursors independent of neuronal wiring. In addition, we target the keratin 15 gene to generate stuck-in-the-midline (siml) mutants, which display epithelial lesions and a disrupted pLL patterning. By using siml/wt chimeras, we determine that the aberrant siml pLL pattern depends on the mutant epithelium, since a wild type epithelium can rescue the siml phenotype. Inducing epithelial lesions by 2-photon laser ablation during pLL morphogenesis phenocopies siml genetic mutants and reveals that epithelial integrity defines the final position of the embryonic pLL neuromasts. Our results using the medaka pLL disentangle intrinsic from extrinsic properties during the establishment of a sensory system. We speculate that intrinsic programs guarantee proper organ morphogenesis, while instructive interactions from surrounding tissues facilitates the accommodation of sensory organs to the diverse body plans found among teleosts.
DOI:doi:10.1016/j.ydbio.2021.09.002
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1016/j.ydbio.2021.09.002
 Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DynamicDOIArticle&SrcApp=WOS&KeyAID=10.1016%2 ...
 DOI: https://doi.org/10.1016/j.ydbio.2021.09.002
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:adaptive evolution
 cis-regulatory changes
 Epithelial cells
 fish
 hair-cell regeneration
 Keratin
 Keratin 15
 Lateral line
 Medaka
 migration
 Pattern formation
 phenotypes
 postembryonic development
 posterior lateral-line
 Sensory system
 stem-cells
 zebrafish
K10plus-PPN:1777269571
Verknüpfungen:→ Zeitschrift

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