| |  Online-Ressource |
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| Verfasst von: | Nakata, Susumu [VerfasserIn]  |
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| | Campos, Benito [VerfasserIn] |
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| | Bageritz, Josephine [VerfasserIn] |
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| | Lorenzo Bermejo, Justo [VerfasserIn] |
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| | Becker, Natalia [VerfasserIn] |
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| | Engel, Felix [VerfasserIn] |
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| | Acker, Till [VerfasserIn] |
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| | Momma, Stefan [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Radlwimmer, Bernhard [VerfasserIn] |
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| | Goidts, Violaine [VerfasserIn] |
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| Titel: | LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells |
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| Verf.angabe: | Susumu Nakata; Benito Campos; Josephine Bageritz; Justo Lorenzo Bermejo; Natalia Becker; Felix Engel; Till Acker; Stefan Momma; Christel Herold-Mende; Peter Lichter; Bernhard Radlwimmer; Violaine Goidts |
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| Jahr: | 2013 |
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| Umfang: | 13 S. |
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| Fussnoten: | Published online article accepted: 16 July 2012 ; Gesehen am 24.11.2021 |
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| Titel Quelle: | Enthalten in: Brain pathology |
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| Ort Quelle: | Oxford : Wiley-Blackwell, 1990 |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 23(2013), 1, Seite 60-72 |
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| ISSN Quelle: | 1750-3639 |
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| Abstract: | In various types of cancers including glioblastoma, accumulating evidence show the existence of cancer stem-like cells (CSCs), characterized by stem cell marker expression, capability of differentiation and self-renewal, and high potential for tumor propagation in vivo. LGR5, whose expression is positively regulated by the Wnt signaling pathway, is a stem cell marker in intestinal mucosa and hair follicle in the skin. As Wnt signaling is also involved in brain development, the function of LGR5 in the maintenance of brain CSCs is to be assessed. Our study showed that the LGR5 transcript level was increased in CSCs. Co-immunofluorescence staining demonstrated the co-localization of CD133- and LGR5-positive cells in glioblastoma tissue sections. Functionally, silencing of LGR5 by lentiviral shRNA-mediated knockdown induced apoptosis in brain CSCs. Moreover, LGR5 depletion led to a downregulation of L1 cell adhesion molecule expression. In line with an important function in glioma tumorigenesis, LGR5 expression increased with glioma progression and correlated with an adverse outcome. Our findings suggest that LGR5 plays a role in maintenance and/or survival of brain CSCs. |
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| DOI: | doi:10.1111/j.1750-3639.2012.00618.x |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1111/j.1750-3639.2012.00618.x |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1750-3639.2012.00618.x |
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| | DOI: https://doi.org/10.1111/j.1750-3639.2012.00618.x |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | apoptosis |
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| | cancer stem cell |
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| | glioblastoma |
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| | glioma |
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| | LGR5 |
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| K10plus-PPN: | 1777942179 |
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| Verknüpfungen: | → Zeitschrift |
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LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells / Nakata, Susumu [VerfasserIn]; 2013 (Online-Ressource)
