| |  Online-Ressource |
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| Verfasst von: | Wolff, Anette S. B. [VerfasserIn]  |
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| | Braun, Sarah [VerfasserIn] |
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| | Husebye, Eystein S. [VerfasserIn] |
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| | Oftedal, Bergithe E. [VerfasserIn] |
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| Titel: | B cells and autoantibodies in AIRE deficiency |
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| Verf.angabe: | Anette S.B. Wolff, Sarah Braun, Eystein S. Husebye and Bergithe E. Oftedal |
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| E-Jahr: | 2021 |
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| Jahr: | 21 September 2021 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 02.12.2021 |
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| Titel Quelle: | Enthalten in: Biomedicines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 9(2021), 9, Artikel-ID 1274, Seite 1-15 |
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| ISSN Quelle: | 2227-9059 |
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| Abstract: | Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare but severe monogenetic autoimmune endocrine disease caused by failure of the Autoimmune Regulator (AIRE). AIRE regulates the negative selection of T cells in the thymus, and the main pathogenic mechanisms are believed to be T cell-mediated, but little is known about the role of B cells. Here, we give an overview of the role of B cells in thymic and peripheral tolerance in APS-1 patients and different AIRE-deficient mouse models. We also look closely into which autoantibodies have been described for this disorder, and their implications. Based on what is known about B cell therapy in other autoimmune disorders, we outline the potential of B cell therapies in APS-1 and highlight the unresolved research questions to be answered. |
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| DOI: | doi:10.3390/biomedicines9091274 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/biomedicines9091274 |
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| | Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.3390%2Fbiomedi ... |
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| | DOI: https://doi.org/10.3390/biomedicines9091274 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | amino-acid decarboxylase |
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| | autoantibodies |
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| | autoimmune polyendocrine syndrome type 1 (APS-1) |
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| | autoimmune regulator gene |
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| | B-cell dependent therapy |
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| | B-cells |
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| | candidiasis-ectodermal dystrophy |
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| | chronic mucocutaneous candidiasis |
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| | monoclonal-antibodies |
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| | mouse models of Aire deficiency |
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| | polyendocrine syndrome type-1 |
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| | polyglandular syndrome type-1 |
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| | syndrome type-i |
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| | t-cells |
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| | tryptophan-hydroxylase autoantibodies |
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| K10plus-PPN: | 1780157894 |
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| Verknüpfungen: | → Zeitschrift |
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B cells and autoantibodies in AIRE deficiency / Wolff, Anette S. B. [VerfasserIn]; 21 September 2021 (Online-Ressource)
