| Online-Ressource |
Verfasst von: | Wolff, Anette S. B. [VerfasserIn]  |
| Braun, Sarah [VerfasserIn]  |
| Husebye, Eystein S. [VerfasserIn]  |
| Oftedal, Bergithe E. [VerfasserIn]  |
Titel: | B cells and autoantibodies in AIRE deficiency |
Verf.angabe: | Anette S.B. Wolff, Sarah Braun, Eystein S. Husebye and Bergithe E. Oftedal |
E-Jahr: | 2021 |
Jahr: | 21 September 2021 |
Umfang: | 15 S. |
Fussnoten: | Gesehen am 02.12.2021 |
Titel Quelle: | Enthalten in: Biomedicines |
Ort Quelle: | Basel : MDPI, 2013 |
Jahr Quelle: | 2021 |
Band/Heft Quelle: | 9(2021), 9, Artikel-ID 1274, Seite 1-15 |
ISSN Quelle: | 2227-9059 |
Abstract: | Autoimmune polyendocrine syndrome type 1 (APS-1) is a rare but severe monogenetic autoimmune endocrine disease caused by failure of the Autoimmune Regulator (AIRE). AIRE regulates the negative selection of T cells in the thymus, and the main pathogenic mechanisms are believed to be T cell-mediated, but little is known about the role of B cells. Here, we give an overview of the role of B cells in thymic and peripheral tolerance in APS-1 patients and different AIRE-deficient mouse models. We also look closely into which autoantibodies have been described for this disorder, and their implications. Based on what is known about B cell therapy in other autoimmune disorders, we outline the potential of B cell therapies in APS-1 and highlight the unresolved research questions to be answered. |
DOI: | doi:10.3390/biomedicines9091274 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.3390/biomedicines9091274 |
| Volltext: https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=DOISource&SrcApp=WOS&KeyAID=10.3390%2Fbiomedi ... |
| DOI: https://doi.org/10.3390/biomedicines9091274 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | amino-acid decarboxylase |
| autoantibodies |
| autoimmune polyendocrine syndrome type 1 (APS-1) |
| autoimmune regulator gene |
| B-cell dependent therapy |
| B-cells |
| candidiasis-ectodermal dystrophy |
| chronic mucocutaneous candidiasis |
| monoclonal-antibodies |
| mouse models of Aire deficiency |
| polyendocrine syndrome type-1 |
| polyglandular syndrome type-1 |
| syndrome type-i |
| t-cells |
| tryptophan-hydroxylase autoantibodies |
K10plus-PPN: | 1780157894 |
Verknüpfungen: | → Zeitschrift |
B cells and autoantibodies in AIRE deficiency / Wolff, Anette S. B. [VerfasserIn]; 21 September 2021 (Online-Ressource)