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| Verfasst von: | Hofmann, Diana [VerfasserIn]  |
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| | Garg, Niharika [VerfasserIn] |
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| | Grässle, Simone [VerfasserIn] |
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| | Vanderheiden, Sylvia [VerfasserIn] |
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| | Bergheim, Bruno Gideon [VerfasserIn] |
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| | Bräse, Stefan [VerfasserIn] |
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| | Jung, Nicole [VerfasserIn] |
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| | Özbek, Suat [VerfasserIn] |
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| Titel: | A small molecule screen identifies novel inhibitors of mechanosensory nematocyst discharge in Hydra |
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| Verf.angabe: | Diana Hofmann, Niharika Garg, Simone Grässle, Sylvia Vanderheiden, Bruno Gideon Bergheim, Stefan Bräse, Nicole Jung & Suat Özbek |
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| E-Jahr: | 2021 |
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| Jahr: | 18 October 2021 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 09.02.2022 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Macmillan Publishers Limited, part of Springer Nature, 2011 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 11(2021), Artikel-ID 20627, Seite 1-11 |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Cnidarians are characterized by the possession of stinging organelles, called nematocysts, which they use for prey capture and defense. Nematocyst discharge is controlled by a mechanosensory apparatus with analogies to vertebrate hair cells. Members of the transient receptor potential (TRPN) ion channel family are supposed to be involved in the transduction of the mechanical stimulus. A small molecule screen was performed to identify compounds that affect nematocyst discharge in Hydra. We identified several [2.2]paracyclophanes that cause inhibition of nematocyst discharge in the low micro-molar range. Further structure-activity analyses within the compound class of [2.2] paracyclophanes showed common features that are required for the inhibitory activity of the [2.2] paracyclophane core motif. This study demonstrates that Hydra can serve as a model for small molecule screens targeting the mechanosensory apparatus in native tissues. |
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| DOI: | doi:10.1038/s41598-021-99974-7 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1038/s41598-021-99974-7 |
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| | DOI: https://doi.org/10.1038/s41598-021-99974-7 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | ankyrin repeats |
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| | ion-channel |
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| | nompc |
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| | tentacles |
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| K10plus-PPN: | 1789043743 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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¬A¬ small molecule screen identifies novel inhibitors of mechanosensory nematocyst discharge in Hydra / Hofmann, Diana [VerfasserIn]; 18 October 2021 (Online-Ressource)
