| Online-Ressource |
Verfasst von: | Liesz, Arthur [VerfasserIn]  |
| Zhou, Wei [VerfasserIn]  |
| Na, Shin-Young [VerfasserIn]  |
| Hämmerling, Günter J. [VerfasserIn]  |
| Garbi, Natalio [VerfasserIn]  |
| Karcher-Bausch, Simone [VerfasserIn]  |
| Mracskó, Eva [VerfasserIn]  |
| Backs, Johannes [VerfasserIn]  |
| Rivest, Serge [VerfasserIn]  |
| Veltkamp, Roland [VerfasserIn]  |
Titel: | Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke |
Verf.angabe: | Arthur Liesz, Wei Zhou, Shin-Young Na, Günter J. Hämmerling, Natalio Garbi, Simone Karcher, Eva Mracsko, Johannes Backs, Serge Rivest, and Roland Veltkamp |
E-Jahr: | 2013 |
Jahr: | October 30, 2013 |
Umfang: | 13 S. |
Fussnoten: | Gesehen am 03.03.2022 |
Titel Quelle: | Enthalten in: The journal of neuroscience |
Ort Quelle: | Washington, DC : Soc., 1981 |
Jahr Quelle: | 2013 |
Band/Heft Quelle: | 33(2013), 44 vom: Okt., Seite 17350-17362 |
ISSN Quelle: | 1529-2401 |
Abstract: | Inflammatory mechanisms contribute substantially to secondary tissue injury after brain ischemia. Regulatory T cells (Tregs) are key endogenous modulators of postischemic neuroinflammation. We investigated the potential of histone deacetylase inhibition (HDACi) to enhance Treg potency for experimental stroke in mice. HDACi using trichostatin A increased the number of Tregs and boosted their immunosuppressive capacity and interleukin (IL)-10 expression. In vivo treatment reduced infarct volumes and behavioral deficits after cortical brain ischemia, attenuated cerebral proinflammatory cytokine expression, and increased numbers of brain-invading Tregs. A similar effect was obtained using tubastatin, a specific inhibitor of HDAC6 and a key HDAC in Foxp3 regulation. The neuroprotective effect of HDACi depended on the presence of Foxp3+ Tregs, and in vivo and in vitro studies showed that the anti-inflammatory cytokine IL-10 was their main mediator. In summary, modulation of Treg function by HDACi is a novel and potent target to intervene at the center of neuroinflammation. Furthermore, this novel concept of modulating endogenous immune mechanisms might be translated to a broad spectrum of diseases, including primary neuroinflammatory and neurodegenerative disorders. |
DOI: | doi:10.1523/JNEUROSCI.4901-12.2013 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1523/JNEUROSCI.4901-12.2013 |
| Volltext: https://www.jneurosci.org/content/33/44/17350 |
| DOI: https://doi.org/10.1523/JNEUROSCI.4901-12.2013 |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1794537201 |
Verknüpfungen: | → Zeitschrift |
Boosting regulatory T cells limits neuroinflammation in permanent cortical stroke / Liesz, Arthur [VerfasserIn]; October 30, 2013 (Online-Ressource)