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Verfasst von:Hennerici, Michael G. [VerfasserIn]   i
Titel:The unstable plaque
Verf.angabe:Michael G. Hennerici
E-Jahr:2004
Jahr:January 23, 2004
Umfang:6 S.
Fussnoten:Gesehen am 23.05.2022
Titel Quelle:Enthalten in: Cerebrovascular diseases
Ort Quelle:Basel : Karger, 1991
Jahr Quelle:2004
Band/Heft Quelle:17(2004), Suppl. 3, Seite 17-22
ISSN Quelle:1421-9786
Abstract:Ischaemic strokes and transient ischaemic attacks are commonly caused by cerebral embolism originating from formation of a platelet-rich thrombus superimposed on an atherosclerotic plaque or by atherothrombotic plaque rupture in a carotid or intracranial artery. Despite advances made through ultrasound imaging in our understanding of atherosclerotic plaque progression and regression, the issue of whether differences in plaque structure alone can distinguish between lesions that become symptomatic and others that remain clinically silent continues to be debated. Recent biochemical and imaging studies have identified characteristics that may reflect a high risk of vulnerability, such as outward, abluminal plaque remodelling, the presence of intra-plaque haemorrhage, inflammation, severe flow disturbances around the encroaching lesion, plaque cap thinning and ulceration, and abnormal plaque motion. Plaque stability may be improved through management of traditional cardiovascular risk factors or with biological or pharmacological agents that target pathways involved in plaque pathophysiology. Unstable plaques place patients at risk of unpredictable ischaemic events and in patients with such lesions, specific preventive treatment beyond long-term antiplatelet therapy can be used to prevent new or recurrent events.
DOI:doi:10.1159/000075300
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1159/000075300
 DOI: https://doi.org/10.1159/000075300
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Carotid Artery Diseases
 Carotid Artery, Common
 Humans
 Intracranial Embolism
 Intracranial Thrombosis
 Ischemic Attack, Transient
 Platelet Activation
 Platelet Aggregation
 Risk Factors
 Stroke
 Tunica Intima
K10plus-PPN:1804096318
Verknüpfungen:→ Zeitschrift

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