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Status: Bibliographieeintrag

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Verfasst von:Patra, Pintu [VerfasserIn]   i
 Beyer, Konrad [VerfasserIn]   i
 Jaiswal, Astha [VerfasserIn]   i
 Battista, Anna [VerfasserIn]   i
 Rohr, Karl [VerfasserIn]   i
 Frischknecht, Friedrich [VerfasserIn]   i
 Schwarz, Ulrich S. [VerfasserIn]   i
Titel:Collective migration reveals mechanical flexibility of malaria parasites
Verf.angabe:Pintu Patra, Konrad Beyer, Astha Jaiswal, Anna Battista, Karl Rohr, Friedrich Frischknecht and Ulrich S. Schwarz
E-Jahr:2022
Jahr:13 May 2022
Umfang:10 S.
Fussnoten:Gesehen am 01.06.2022
Titel Quelle:Enthalten in: Nature physics
Ort Quelle:Basingstoke : Nature Publishing Group, 2005
Jahr Quelle:2022
Band/Heft Quelle:18(2022), 5, Seite 586-594
ISSN Quelle:1745-2481
Abstract:Plasmodium sporozoites are the crescent-shaped forms of malaria parasites injected from the salivary glands of mosquitoes into the skins of their vertebrate hosts. To proceed towards the liver of the host, sporozoites individually migrate at very high speeds and with relatively few adhesive interactions. By contrast, in the mosquito sporozoites often exist as collectives. Here we study their motion in collectives extracted from salivary glands, a situation in which dozens of sporozoites form rotating vortices. Complementing our experiments with quantitative image analysis and agent-based computer simulations, we find that, owing to their mechanical flexibility, single sporozoites are sorted according to their curvatures and speeds, and that these effects increase with vortex size. We also find that the vortices undergo oscillatory breathing because the thrust from the motility force of the single sporozoites can be stored in their elastic energy. Our findings suggest that the malaria parasite has evolved flexibility as an essential means to adapt to its mechanical environment and to ensure efficient transmission. In general, our work demonstrates how single-particle shape and mechanics can determine the dynamics of large, active collectives.
DOI:doi:10.1038/s41567-022-01583-2
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1038/s41567-022-01583-2
 Volltext: https://www.nature.com/articles/s41567-022-01583-2
 DOI: https://doi.org/10.1038/s41567-022-01583-2
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Biological physics
 Computational biophysics
 Motility
K10plus-PPN:1805520121
Verknüpfungen:→ Zeitschrift

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