Simon's minimax and optimal and Jung's admissible two-stage designs with or without curtailment

• Verfasst von: Kunz, Cornelia Ursula [VerfasserIn]
• Verfasst von: Kieser, Meinhard [VerfasserIn]
• Titel: Simon's minimax and optimal and Jung's admissible two-stage designs with or without curtailment
• Verf.angabe: Cornelia U. Kunz, Meinhard Kieser
• E-Jahr: 2011
• Jahr: July 1, 2011
• Umfang: 15 S.
• Fussnoten: Gesehen am 11.07.2022
• Titel Quelle: Enthalten in: The Stata journal
• Ort Quelle: Thousand Oaks, Calif. : Sage Publishing, 2001
• Jahr Quelle: 2011
• Band/Heft Quelle: 11(2011), 2, Seite 240-254
• ISSN Quelle: 1536-8734
• DOI: doi:10.1177/1536867X1101100205
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: conditional power
• Sach-SW: curtailment
• Sach-SW: Jung's admissible design
• Sach-SW: phase II trials
• Sach-SW: Simon's two-stage design
• Sach-SW: simontwostage
• Sach-SW: st0227
• K10plus-PPN: 1809703093

Abstract

This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials. Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1-10) and admissible designs described by Jung et al. (2004, Statistics in Medicine 23: 561-569). Furthermore, nonstochastic and stochastic curtailment rules can be implemented in both stages of the trial, and the properties of the curtailed designs can be examined.