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Status: Bibliographieeintrag

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Verfasst von:Lenz, Lena-Solveig [VerfasserIn]   i
 Marx, Jana Corinna [VerfasserIn]   i
 Chamulitrat, Walee [VerfasserIn]   i
 Kaiser, Iris [VerfasserIn]   i
 Gröne, Hermann-Josef [VerfasserIn]   i
 Liebisch, Gerhard [VerfasserIn]   i
 Schmitz, Gerd [VerfasserIn]   i
 Elsing, Christoph [VerfasserIn]   i
 Straub, Beate Katharina [VerfasserIn]   i
 Füllekrug, Joachim [VerfasserIn]   i
 Stremmel, Wolfgang [VerfasserIn]   i
 Herrmann, Thomas [VerfasserIn]   i
Titel:Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet
Verf.angabe:Lena-Solveig Lenz, Jana Marx, Walee Chamulitrat, Iris Kaiser, Hermann-Josef Gröne, Gerhard Liebisch, Gerd Schmitz, Christoph Elsing, Beate K. Straub, Joachim Füllekrug, Wolfgang Stremmel, and Thomas Herrmann
E-Jahr:2011
Jahr:July 31, 2011
Umfang:10 S.
Fussnoten:Gesehen am 17.08.2022
Titel Quelle:Enthalten in: The journal of biological chemistry
Ort Quelle:Bethesda, Md. : ASBMB Publications, 1905
Jahr Quelle:2011
Band/Heft Quelle:286(2011), 41, Seite 35578-35587
ISSN Quelle:1083-351X
Abstract:Fatp4 exhibits acyl-CoA synthetase activity and is thereby able to catalyze the activation of fatty acids for further metabolism. However, its actual function in most tissues remains unresolved, and its role in cellular fatty acid uptake is still controversial. To characterize Fatp4 functions in adipocytes in vivo, we generated a mouse line with adipocyte-specific inactivation of the Fatp4 gene (Fatp4A−/−). Under standard conditions mutant mice showed no phenotypical aberrance. Uptake of radiolabeled palmitic and lignoceric acid into adipose tissue of Fatp4A−/− mice was unchanged. When exposed to a diet enriched in long chain fatty acids, Fatp4A−/− mice gained more body weight compared with control mice, although they were not consuming more food. Pronounced obesity was accompanied by a thicker layer of subcutaneous fat and greater adipocyte circumference, although expression of genes involved in de novo lipogenesis was not changed. However, the increase in total fat mass was contrasted by a significant decrease in various phospholipids, sphingomyelin, and cholesteryl esters in adipocytes. Livers of Fatp4-deficient animals under a high fat diet exhibited a higher degree of fatty degeneration. Nonetheless, no evidence for changes in insulin sensitivity and adipose inflammation was found. In summary, the results of this study confirm that Fatp4 is not crucial for fatty acid uptake into adipocytes. Instead, under the condition of a diet enriched in long chain fatty acids, adipocyte-specific Fatp4 deficiency results in adipose hypertrophy and profound alterations in the metabolism of complex lipids.
DOI:doi:10.1074/jbc.M111.226530
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

kostenfrei: Volltext ; Verlag: https://doi.org/10.1074/jbc.M111.226530
 kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0021925820737646
 DOI: https://doi.org/10.1074/jbc.M111.226530
Datenträger:Online-Ressource
Sprache:eng
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe: Lenz, Lena-Solveig: Adipocyte-specific inactivation of Acyl-CoA synthetase fatty acid transport protein 4 (Fatp4) in mice causes adipose hypertrophy and alterations in metabolism of complex lipids under high fat diet. - 2011
Sach-SW:Adipose Tissue
 Adipose Tissue Metabolism
 Fatp4
 Fatty Acid Metabolism
 Fatty Acid Transport
 Fatty Acid Transport Protein
 Lipids
 Mouse
K10plus-PPN:1814543295
Verknüpfungen:→ Zeitschrift

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