Navigation überspringen
Universitätsbibliothek Heidelberg
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Nees, Timo A. [VerfasserIn]   i
 Zhang, Jiji A. [VerfasserIn]   i
 Platzer, Hadrian [VerfasserIn]   i
 Walker, Tilman [VerfasserIn]   i
 Reiner, Tobias [VerfasserIn]   i
 Tripel, Elena [VerfasserIn]   i
 Moradi, Babak [VerfasserIn]   i
 Rosshirt, Nils [VerfasserIn]   i
Titel:Infiltration profile of regulatory T cells in osteoarthritis-related pain and disability
Verf.angabe:Timo Albert Nees, Jiji Alexander Zhang, Hadrian Platzer, Tilman Walker, Tobias Reiner, Elena Tripel, Babak Moradi and Nils Rosshirt
E-Jahr:2022
Jahr:29 August 2022
Umfang:14 S.
Fussnoten:Gesehen am 18.10.2022
Titel Quelle:Enthalten in: Biomedicines
Ort Quelle:Basel : MDPI, 2013
Jahr Quelle:2022
Band/Heft Quelle:10(2022), 9, Artikel-ID 2111, Seite 1-14
ISSN Quelle:2227-9059
Abstract:Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4+CD25+/high CD127low/−) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions - especially in the SM - are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms.
DOI:doi:10.3390/biomedicines10092111
URL:Volltext: https://doi.org/10.3390/biomedicines10092111
 Volltext: https://www.mdpi.com/2227-9059/10/9/2111
 DOI: https://doi.org/10.3390/biomedicines10092111
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:inflammation
 knee pain
 lymphocytes
 osteoarthritis
 peripheral blood
 regulatory T cells
 synovial fluid
 synovial membrane
 T cells
K10plus-PPN:181912407X
Verknüpfungen:→ Zeitschrift
 
 
Lokale URL UB: Zum Volltext

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68975491   QR-Code
zum Seitenanfang