| |  Online-Ressource |
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| Verfasst von: | Schwerk, Christian [VerfasserIn]  |
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| | Adam, Rüdiger [VerfasserIn] |
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| | Borkowski, Julia [VerfasserIn] |
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| | Rudolph, Henriette [VerfasserIn] |
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| | Klenk, Michael [VerfasserIn] |
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| | Zink, Sascha [VerfasserIn] |
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| | Bechtoldt, Natascha [VerfasserIn] |
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| | Schmidt, Nicole [VerfasserIn] |
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| | Stump-Guthier, Carolin [VerfasserIn] |
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| | Sagar, Anubha [VerfasserIn] |
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| | Spellerberg, Barbara [VerfasserIn] |
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| | Tenenbaum, Tobias [VerfasserIn] |
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| | Koczan, Dirk [VerfasserIn] |
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| | Klein-Hitpass, Ludger [VerfasserIn] |
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| | Schroten, Horst [VerfasserIn] |
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| Titel: | In vitro transcriptome analysis of porcine choroid plexus epithelial cells in response to Streptococcus suis |
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| Titelzusatz: | release of pro-inflammatory cytokines and chemokines |
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| Verf.angabe: | Christian Schwerk, Rüdiger Adam, Julia Borkowski, Henriette Schneider, Michael Klenk, Sascha Zink, Natascha Quednau, Nicole Schmidt, Carolin Stump, Anubha Sagar, Barbara Spellerberg, Tobias Tenenbaum, Dirk Koczan, Ludger Klein-Hitpass, Horst Schroten |
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| E-Jahr: | 2011 |
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| Jahr: | [October 2011] |
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| Umfang: | 10 S. |
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| Illustrationen: | Diagramme |
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| Fussnoten: | Gesehen am 31.10.2022 ; Available online 12 June 2011 |
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| Titel Quelle: | Enthalten in: Microbes and infection |
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| Ort Quelle: | Paris [u.a.] : Elsevier, 1999 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 13(2011), 11 vom: Okt., Seite 953-962 |
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| ISSN Quelle: | 1769-714X |
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| Abstract: | The Gram-positive zoonotic bacterium Streptococcus suis (S. suis) is responsible for a wide range of diseases including meningitis in pigs and humans. The blood-cerebrospinal fluid (CSF) barrier is constituted by the epithelial cells of the choroid plexus, which execute barrier function also after bacteria have entered the central nervous system (CNS). We show that the bacterial capsule, a major virulence factor, strongly attenuates adhesion of S. suis to the apical side of porcine choroid plexus epithelial cells (PCPEC). Oligonucleotide microarray analysis and quantitative PCR surprisingly demonstrated that adherent wild-type and capsule-deficient S. suis influenced expression of a pronounced similar pattern of genes in PCPEC. Investigation of purified capsular material provided no evidence for a significant role of the capsule. Enriched among the regulated genes were those involved in “inflammatory response”, “defense response” and “cytokine activity”. These comprised several cytokines and chemokines including the interleukins 6 and 8, which could be detected on protein level. We show that after infection with S. suis the choroid plexus contributes to the immune response by actively producing cytokines and chemokines. Other virulence factors than the bacterial capsule may be relevant in inducing a strong inflammatory response in the CNS during S. suis meningitis. |
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| DOI: | doi:10.1016/j.micinf.2011.05.012 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.micinf.2011.05.012 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1286457911001432 |
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| | DOI: https://doi.org/10.1016/j.micinf.2011.05.012 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Bibliogr. Hinweis: | Erscheint auch als : Druck-Ausgabe: Schwerk, Christian, 1967 - : In vitro transcriptome analysis of porcine choroid plexus epithelial cells in response to Streptococcus suis. - 2011 |
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| Sach-SW: | Blood-cerebrospinal fluid barrier |
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| | Choroid plexus |
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| | Immune response |
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| | Transcriptome |
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| K10plus-PPN: | 1820332128 |
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| Verknüpfungen: | → Zeitschrift |
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In vitro transcriptome analysis of porcine choroid plexus epithelial cells in response to Streptococcus suis / Schwerk, Christian [VerfasserIn]; [October 2011] (Online-Ressource)
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