Post-translational timing mechanisms of the Drosophila circadian clock

• Verfasst von: Weber, Frank [VerfasserIn]
• Verfasst von: Zorn, Daniela [VerfasserIn]
• Verfasst von: Rademacher, Christoph [VerfasserIn]
• Verfasst von: Hung, Hsiu-Cheng [VerfasserIn]
• Titel: Post-translational timing mechanisms of the Drosophila circadian clock
• Verf.angabe: Frank Weber, Daniela Zorn, Christoph Rademacher, Hsiu-Cheng Hung
• E-Jahr: 2011
• Jahr: 7 April 2011
• Umfang: 7 S.
• Fussnoten: Gesehen am 10.11.2022
• Titel Quelle: Enthalten in: Vereinigung der Europäischen Biochemischen GesellschaftenFEBS letters
• Ort Quelle: Chichester : Wiley, 1968
• Jahr Quelle: 2011
• Band/Heft Quelle: 585(2011), 10 vom: 20. Mai, Seite 1443-1449
• ISSN Quelle: 1873-3468
• DOI: doi:10.1016/j.febslet.2011.04.008
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Circadian clock
• Sach-SW: Drosophila
• Sach-SW: Nucleocytoplasmic transport
• Sach-SW: Phosphorylation
• Sach-SW: Post-translational regulation
• Sach-SW: SUMO
• K10plus-PPN: 1821576810

Abstract

Circadian clocks allow a temporal coordination and segregation of physiological, metabolic, and behavioural processes as well as their synchronization with the environmental cycles of day and night. Circadian regulation thereby provides a vital advantage, improving an organisms’ adaptation to its environment. The molecular clock can be synchronized with environmental cycles of day and night, but is able to maintain a self-sustained molecular oscillation also in the absence of environmental stimuli. Interlocked transcriptional-translational feedback loops were shown to form the basis of circadian clock function in all phyla from bacteria, fungi, plants, insects to humans. More recently post-translational regulation was identified to be equally important, if not sufficient for molecular clock function and accurate timing of circadian transcription. Here we review recent insights into post-translational timing mechanisms that control the circadian clock, with a particular focus on Drosophila. Analogous to transcriptional feedback regulation, circadian clock function in Drosophila appears to rely on inter-connected post-translational timers. Post-translational regulation of clock proteins illustrates mechanisms that allow a precise temporal control of transcription factors in general and of circadian transcription in particular.