Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington's disease

• Verfasst von: Wolf, Robert Christian [VerfasserIn]
• Verfasst von: Sambataro, Fabio [VerfasserIn]
• Verfasst von: Vasic, Nenad [VerfasserIn]
• Verfasst von: Wolf, Nadine D. [VerfasserIn]
• Verfasst von: Thomann, Philipp [VerfasserIn]
• Verfasst von: Landwehrmeyer, G. Bernhard [VerfasserIn]
• Verfasst von: Orth, Michael [VerfasserIn]
• Titel: Longitudinal functional magnetic resonance imaging of cognition in preclinical Huntington's disease
• Verf.angabe: Robert Christian Wolf, Fabio Sambataro, Nenad Vasic, Nadine Donata Wolf, Philipp Arthur Thomann, G. Bernhard Landwehrmeyer, Michael Orth
• E-Jahr: 2011
• Jahr: 25 June 2011
• Umfang: 9 S.
• Fussnoten: Gesehen am 24.11.2022
• Titel Quelle: Enthalten in: Experimental neurology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1959
• Jahr Quelle: 2011
• Band/Heft Quelle: 231(2011), 2 vom: Okt., Seite 214-222
• ISSN Quelle: 1090-2430
• DOI: doi:10.1016/j.expneurol.2011.06.011
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Biomarker
• Sach-SW: Functional magnetic resonance imaging
• Sach-SW: Huntington's disease
• Sach-SW: Preclinical
• Sach-SW: Prefrontal cortex
• Sach-SW: Working memory
• K10plus-PPN: 1823543960

Abstract

Neuropsychological and functional neuroimaging studies have revealed early changes of cognition and brain function in individuals with the Huntington's disease (HD) gene mutation who are presymptomatic for the motor symptoms of the disease (preHD). However, little is known about whether changes of neural function progress over time. In this study, we used neuropsychological tests of attention, working memory and executive function, functional magnetic resonance imaging and voxel-based analyses of high-resolution structural data to explore the temporal dynamics of potential cognitive, functional and structural biomarkers in far from onset preHD (n=13, mean time to the estimated motor symptom onset=19.5years) and healthy controls (n=13) followed over a 2-year period. Behavioral measures were similar in preHD individuals and controls at baseline and remained normal 2years later. At both time points, the left dorsolateral prefrontal cortex was less active in preHD than in controls during working memory performance. The left dorsolateral prefrontal cortex did not exhibit further loss of activity over time. Regions showing less gray matter volume in preHD at baseline did not show further volume loss over time. These data indicate that the activity in brain regions contributing to working memory processing differs consistently in HD expansion mutation carriers while cognitive performance remains normal. However, the present data do not support the notion of a progressive decline of left prefrontal cortex activity in far from onset preHD followed over a 2-year period.