| |  Online-Ressource |
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| Verfasst von: | Meyer, Sören [VerfasserIn]  |
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| | Li, Xue [VerfasserIn] |
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| | Meyer, Carina [VerfasserIn] |
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| | Voloshanenko, Oksana [VerfasserIn] |
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| | Pohl, Susann [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| | Katus, Hugo [VerfasserIn] |
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| | Frey, Norbert [VerfasserIn] |
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| | Leuschner, Florian [VerfasserIn] |
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| Titel: | Blockade of wnt secretion attenuates myocardial ischemia-reperfusion injury by modulating the inflammatory response |
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| Verf.angabe: | Ingmar Sören Meyer, Xue Li, Carina Meyer, Oksana Voloshanenko, Susann Pohl, Michael Boutros, Hugo Albert Katus, Norbert Frey and Florian Leuschner |
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| E-Jahr: | 2022 |
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| Jahr: | 14 October 2022 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 13.12.2022 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 23(2022), 20, Artikel-ID 12252, Seite 1-14 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Wnt (a portmanteau of Wingless and Int-1) signaling in the adult heart is largely quiescent. However, there is accumulating evidence that it gets reactivated during the healing process after myocardial infarction (MI). We here tested the therapeutic potential of the Wnt secretion inhibitor LGK-974 on MI healing. Ischemia/reperfusion (I/R) injury was induced in mice and Wnt signaling was inhibited by oral administration of the porcupine inhibitor LGK-974. The transcriptome was analyzed from infarcted tissue by using RNA sequencing analysis. The inflammatory response after I/R was evaluated by flow cytometry. Heart function was assessed by echocardiography and fibrosis by Masson’s trichrome staining. Transcriptome and gene set enrichment analysis revealed a modulation of the inflammatory response upon administration of the Wnt secretion inhibitor LGK-974 following I/R. In addition, LGK-974-treated animals showed an attenuated inflammatory response and improved heart function. In an in vitro model of hypoxic cardiomyocyte and monocyte/macrophage interaction, LGK974 inhibited the activation of Wnt signaling in monocytes/macrophages and reduced their pro-inflammatory phenotype. We here show that Wnt signaling affects inflammatory processes after MI. The Wnt secretion inhibitor LGK-974 appears to be a promising compound for future immunomodulatory approaches to improve cardiac remodeling after MI. |
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| DOI: | doi:10.3390/ijms232012252 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms232012252 |
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| | Volltext: https://www.mdpi.com/1422-0067/23/20/12252 |
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| | DOI: https://doi.org/10.3390/ijms232012252 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | inflammation |
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| | monocytes |
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| | myocardial infarction |
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| | Wnt signaling |
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| K10plus-PPN: | 1826872000 |
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| Verknüpfungen: | → Zeitschrift |
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Blockade of wnt secretion attenuates myocardial ischemia-reperfusion injury by modulating the inflammatory response / Meyer, Sören [VerfasserIn]; 14 October 2022 (Online-Ressource)
