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Verfasst von:Zhang, Shaoxiong [VerfasserIn]   i
 Duangjan, Chatrawee [VerfasserIn]   i
 Tencomnao, Tewin [VerfasserIn]   i
 Wu, Liangyu [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
 Lin, Jinke [VerfasserIn]   i
Titel:Oolonghomobisflavans exert neuroprotective activities in cultured neuronal cells and anti-aging effects in Caenorhabditis elegans
Verf.angabe:Shaoxiong Zhang, Chatrawee Duangjan, Tewin Tencomnao, Liangyu Wu, Michael Wink and Jinke Lin
E-Jahr:2022
Jahr:07 September 2022
Umfang:15 S.
Fussnoten:Gesehen am 11.01.2023
Titel Quelle:Enthalten in: Frontiers in aging neuroscience
Ort Quelle:Lausanne : Frontiers Research Foundation, 2010
Jahr Quelle:2022
Band/Heft Quelle:14(2022) vom: Sept., Artikel-ID 967316, Seite 1-15
ISSN Quelle:1663-4365
Abstract:Potential health benefits of tea has attracted significant scientific and public attention worldwide. Tea polyphenols are considered as natural promising complementary therapeutical agents for neurodegenerative diseases. However, the anti-neurodegeneration or anti-aging activities of oolong tea polyphenols have not been investigated. The current study aims to document beneficial effects of oolong tea polyphenols [dimers of epigallocatechin gallate (EGCG), oolonghomobisflavan A (OFA), and oolonghomobisflavan B (OFB)] with neuroprotective and neuritogenesis properties in cultured neuronal (Neuro-2a and HT22) cells and Caenorhabditis elegans models. In vitro, we found that the compounds (EGCG, OFA, and OFB) protect against glutamate-induced neurotoxicity via scavenging radical activity, suppression intracellular ROS and up-regulation of antioxidant enzymes. Moreover, the compounds induce neurite outgrowth via up-regulate Ten-4 gene expression. Interestingly, OFA and OFB exert stronger neuroprotective and neurite outgrowth properties than EGCG known as an excellent antioxidant agent in tea. In vivo, we found that the compounds protect against C. elegans Aβ-induced paralysis, chemotaxis deficiency and α-synuclein aggregation. Moreover, the compounds are capable of extending the lifespan of C. elegans. OFA and OFB possess both anti-neurodegeneration and anti-aging activities, supporting its therapeutic potential for the treatment of age-related neurodegenerative diseases which need to be studied in more detail in intervention studies.
DOI:doi:10.3389/fnagi.2022.967316
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.3389/fnagi.2022.967316
 Volltext: https://www.frontiersin.org/articles/10.3389/fnagi.2022.967316
 DOI: https://doi.org/10.3389/fnagi.2022.967316
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1830734121
Verknüpfungen:→ Zeitschrift

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