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| Verfasst von: | Freischmidt, Holger [VerfasserIn]  |
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| | Armbruster, Jonas [VerfasserIn] |
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| | Rothhaas, Catharina [VerfasserIn] |
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| | Titze, Nadine [VerfasserIn] |
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| | Gühring, Thorsten [VerfasserIn] |
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| | Nurjadi, Dennis [VerfasserIn] |
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| | Kretzer, Jan Philippe [VerfasserIn] |
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| | Schmidmaier, Gerhard [VerfasserIn] |
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| | Grützner, Paul Alfred [VerfasserIn] |
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| | Helbig, Lars [VerfasserIn] |
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| Titel: | Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions |
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| Verf.angabe: | Holger Freischmidt, Jonas Armbruster, Catharina Rothhaas, Nadine Titze, Thorsten Guehring, Dennis Nurjadi, Jan Philippe Kretzer, Gerhard Schmidmaier, Paul Alfred Grützner and Lars Helbig |
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| E-Jahr: | 2022 |
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| Jahr: | 8 October 2022 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 17.01.2023 |
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| Titel Quelle: | Enthalten in: Biomedicines |
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| Ort Quelle: | Basel : MDPI, 2013 |
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| Jahr Quelle: | 2022 |
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| Band/Heft Quelle: | 10(2022), 10, Artikel-ID 2513, Seite 1-17 |
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| ISSN Quelle: | 2227-9059 |
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| Abstract: | The treatment of non-unions is often complicated by segmental bone defects and bacterial colonization. Because of the limited availability of autologous bone grafts, tissue engineering focuses on antibiotic-loaded bone graft substitutes. HACaS+G is a resorbable calcium sulphate-hydroxyapatite loaded with gentamicin. The osteoinductive, osteoconductive, and anti-infective effect of HACaS+G has already been demonstrated in clinical studies on patients with chronic osteomyelitis. However, especially for the treatment of infected non-unions with segmental bone defects by HACaS+G, reliable clinical testing is difficult and sufficient experimental data are lacking. We used an already established sequential animal model in infected and non-infected rat femora to investigate the osteoinductive, osteoconductive, and anti-infective efficacy of HACaS+G for the treatment of infected non-unions. In biomechanical testing, bone consolidation could not be observed under infected and non-infected conditions. Only a prophylactic effect against infections, but no eradication, could be verified in the microbiological analysis. Using µ-CT scans and histology, osteoinduction was detected in both the infected and non-infected bone, whereas osteoconduction occurred only in the non-infected setting. Our data showed that HACaS+G is osteoinductive, but does not have added benefits in infected non-unions in terms of osteoconduction and mechanical bone stability, especially in those with segmental bone defects. |
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| DOI: | doi:10.3390/biomedicines10102513 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/biomedicines10102513 |
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| | Volltext: https://www.mdpi.com/2227-9059/10/10/2513 |
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| | DOI: https://doi.org/10.3390/biomedicines10102513 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | animal model |
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| | bone defect |
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| | bone infection |
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| | ceramic-based bone graft substitute |
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| | non-union |
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| | osteitis |
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| K10plus-PPN: | 183124070X |
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| Verknüpfungen: | → Zeitschrift |
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Efficacy of an antibiotic loaded ceramic-based bone graft substitute for the treatment of infected non-unions / Freischmidt, Holger [VerfasserIn]; 8 October 2022 (Online-Ressource)
