| |  Online resource |
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| Verfasst von: | Laqmani-Goffinet, Christine [VerfasserIn]  |
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| | Homann, Stefanie [VerfasserIn] |
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| | Ambiel, Ina [VerfasserIn] |
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| | Tibroni, Nadine [VerfasserIn] |
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| | Rupp, Daniel [VerfasserIn] |
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| | Keppler, Oliver Till [VerfasserIn] |
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| | Fackler, Oliver Till [VerfasserIn] |
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| Titel: | Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu |
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| Verf.angabe: | Christine Goffinet, Stefanie Homann, Ina Ambiel, Nadine Tibroni, Daniel Rupp, Oliver T. Keppler, and Oliver T. Fackler |
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| E-Jahr: | 2010 |
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| Jahr: | 31 January 2010 |
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| Umfang: | 6 S. |
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| Fussnoten: | Gesehen am 17.04.2023 |
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| Titel Quelle: | Enthalten in: Journal of virology |
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| Ort Quelle: | Baltimore, Md. : Soc., 1967 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 84(2010), 8, Seite 4089-4094 |
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| ISSN Quelle: | 1098-5514 |
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| Abstract: | Vpu antagonizes human immunodeficiency virus type 1 (HIV-1) particle release inhibition by CD317/BST-2/Tetherin. Whether this Vpu activity strictly requires cellular depletion of the restriction factor is unclear. Here, we characterized CD317 variants with mutations in putative sorting or ubiquitination motifs. All mutants still potently impaired release of Vpu-defective HIV-1 and remained sensitive to Vpu-mediated release enhancement. Importantly, this virological antagonism correlated with surface downregulation of CD317 mutants by Vpu, while intracellular pools of these mutants, which were consistently depleted of the wild-type protein, were highly variable or even enhanced. Thus, Vpu can efficiently antagonize virion tethering in the absence of CD317 degradation. |
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| DOI: | doi:10.1128/JVI.01549-09 |
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| URL: | Bibliographic entry. University members only receive access to full-texts for open access or licensed publications.
DOI: https://doi.org/10.1128/JVI.01549-09 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Antigens, CD |
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| | GPI-Linked Proteins |
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| | HIV-1 |
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| | Human Immunodeficiency Virus Proteins |
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| | Humans |
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| | Membrane Glycoproteins |
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| | Membrane Proteins |
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| | Mutant Proteins |
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| | Viral Regulatory and Accessory Proteins |
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| | Virulence Factors |
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| K10plus-PPN: | 1842952153 |
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| Verknüpfungen: | → Journal |
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Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu / Laqmani-Goffinet, Christine [VerfasserIn]; 31 January 2010 (Online-Ressource)
