| |  Online-Ressource |
|---|
| Verfasst von: | Pfister, Frederick [VerfasserIn]  |
|---|
| | Wang, Yumei [VerfasserIn] |
|---|
| | Schreiter, Kay [VerfasserIn] |
|---|
| | vom Hagen, Franziska [VerfasserIn] |
|---|
| | Altvater, Karin [VerfasserIn] |
|---|
| | Hoffmann, Sigrid [VerfasserIn] |
|---|
| | Deutsch, Urban [VerfasserIn] |
|---|
| | Hammes, Hans-Peter [VerfasserIn] |
|---|
| | Feng, Yuxi [VerfasserIn] |
|---|
| Titel: | Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia |
|---|
| Verf.angabe: | Frederick Pfister, Yumei Wang, Kay Schreiter, Franziska vom Hagen, Karin Altvater, Sigrid Hoffmann, Urban Deutsch, Hans-Peter Hammes, Yuxi Feng |
|---|
| Jahr: | 2010 |
|---|
| Fussnoten: | Online veröffentlicht: 24. Februar 2009 ; Gesehen am 02.05.2023 |
|---|
| Titel Quelle: | Enthalten in: Acta diabetologica |
|---|
| Ort Quelle: | Mailand : Springer, 1991 |
|---|
| Jahr Quelle: | 2010 |
|---|
| Band/Heft Quelle: | 47(2010), Seite 59-64$i6 |
|---|
| ISSN Quelle: | 1432-5233 |
|---|
| Abstract: | Our previous data suggested that angiopoietin-2 (Ang-2) is linked to pericyte loss, thereby playing an important role in diabetic retinopathy. In this study, we investigated the effect of retinal overexpression of human Ang-2 (mOpsinhAng2 mouse) on vascular morphology in non-diabetic and streptozotozin-induced diabetic animals. Pericyte (PC) coverage and acellular capillary (AC) formation were quantitated in retinal digest preparations after 3 and 6 months of diabetes duration. The degree of retinopathy in non-diabetic mOpsinhAng2 mice at 3 months (−21% PC, +49% AC) was comparable to age-matched diabetic wild type mice. Diabetic mOpsinhAng2 mice exhibited significantly worse vascular pathology than wild type counterparts at 6 months. Quantitative PCR revealed that human Ang-2 mRNA was highly overexpressed in retinas of transgenic mice. Our data demonstrate that overexpression of Ang-2 in the retina enhances vascular pathology, indicating that Ang-2 plays an essential role in diabetic vasoregression via destabilization of pericytes. |
|---|
| DOI: | doi:10.1007/s00592-009-0099-2 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00592-009-0099-2 |
|---|
| | DOI: https://doi.org/10.1007/s00592-009-0099-2 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Angiopoietin-2 |
|---|
| | Diabetic retinopathy |
|---|
| | Pericyte |
|---|
| K10plus-PPN: | 1844099555 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Retinal overexpression of angiopoietin-2 mimics diabetic retinopathy and enhances vascular damages in hyperglycemia / Pfister, Frederick [VerfasserIn]; 2010 (Online-Ressource)
