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Verfasst von:Herrmann, Edwin [VerfasserIn]   i
 Trojan, Lutz [VerfasserIn]   i
 Becker, Frank [VerfasserIn]   i
 Wülfing, Christian [VerfasserIn]   i
 Schrader, Andres J. [VerfasserIn]   i
 Barth, Peter [VerfasserIn]   i
 Stöckle, Michael [VerfasserIn]   i
 Hammerschmied, Christine G. [VerfasserIn]   i
 Staehler, Michael [VerfasserIn]   i
 Stief, Christian [VerfasserIn]   i
 Haferkamp, Axel [VerfasserIn]   i
 Hohenfellner, Markus [VerfasserIn]   i
 Legal, Wolfgang [VerfasserIn]   i
 Wullich, Bernd [VerfasserIn]   i
 Bolenz, Christian [VerfasserIn]   i
 Klein, Tobias [VerfasserIn]   i
 Noldus, Joachim [VerfasserIn]   i
 Bierer, Stefan [VerfasserIn]   i
 Hertle, Lothar [VerfasserIn]   i
 Brenner, Walpurgis [VerfasserIn]   i
 Roos, Frederik [VerfasserIn]   i
 Michel, Maurice Stephan [VerfasserIn]   i
 Walter, Bernhard [VerfasserIn]   i
 Wieland, Wolf [VerfasserIn]   i
 Gerss, Joachim [VerfasserIn]   i
 Otto, Wolfgang [VerfasserIn]   i
 Hartmann, Arndt [VerfasserIn]   i
Titel:Prognostic factors of papillary renal cell carcinoma
Titelzusatz:results from a multi-institutional series after pathological review
Verf.angabe:Edwin Herrmann, Lutz Trojan, Frank Becker, Christian Wülfing, Andres J. Schrader, Peter Barth, Michael Stöckle, Christine G. Hammerschmied, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Wolfgang Legal, Bernd Wullich, Christian Bolenz, Tobias Klein, Joachim Noldus, Stefan Bierer, Lothar Hertle, Walpurgis Brenner, Frederik Roos, Maurice S. Michel, Bernhard Walter, Wolf Wieland, Joachim Gerss, Wolfgang Otto and Arndt Hartmann
E-Jahr:2010
Jahr:1 Feb 2010
Umfang:7 S.
Illustrationen:Diagramme
Fussnoten:Gesehen am 03.05.2023
Titel Quelle:Enthalten in: The journal of urology
Ort Quelle:New York, NY [u.a.] : Elsevier, 1917
Jahr Quelle:2010
Band/Heft Quelle:183(2010), 2 vom: Feb., Seite 460-466
ISSN Quelle:1527-3792
Abstract:Purpose: - - We examined papillary renal cell carcinoma prognostic variables and validated the 2002 UICC TNM staging system in a multicenter analysis. - - Materials and Methods: - - From 10 urological institutions in Germany followup data were collected on a total of 675 patients with papillary renal cell carcinoma. Central pathological review was done to validate external histopathological diagnoses. The Kaplan-Meier method was used to derive cumulative cancer specific and overall survival, and the log rank test was used to compare the curves of 2 or more groups. For multivariate analysis of prognostic factors Cox regression analysis was done. All proportional hazard assumptions were systemically verified using the Grambsch-Therneau test. - - Results: - - Cancer specific survival was significantly related to TNM stage and histological grading on univariate and multivariate analyses. Five-year cancer specific survival in pT1b cases was significantly shorter than in pT1a cases (90.0% vs 98.3%, p = 0.017). No significant difference was found between pT1b and pT2 tumors. Patients with pT3 or greater disease were at high risk for metastasis (50.6%) while metastatic disease associated with pT2 or less tumors occurred in 7.8% (p <0.0001). After metastatic disease was present the prognosis was poor with 7.2% 5-year cancer specific survival. Age was associated with poor prognosis in the subgroup with pT3 or greater tumors on univariate analysis (p = 0.026) but not on multivariate analysis. - - Conclusions: - - In its current form the 2002 UICC TNM staging system is not applicable to papillary renal cell carcinoma. Clinical and radiological followup should be offered at frequent intervals to patients with venous thrombus and/or locally advanced disease. The role of age remains unclear but should not be underestimated in risk stratification after surgery.
DOI:doi:10.1016/j.juro.2009.10.026
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.juro.2009.10.026
 Volltext: https://www.auajournals.org/doi/10.1016/j.juro.2009.10.026
 DOI: https://doi.org/10.1016/j.juro.2009.10.026
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:carcinoma
 kidney
 neoplasm metastasis
 neoplasm staging
 renal cell
 risk
K10plus-PPN:1844414639
Verknüpfungen:→ Zeitschrift

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