On the role of acylation of transmembrane proteins

• Verfasst von: Morozová, Diana [VerfasserIn]
• Verfasst von: Weiß, Matthias [VerfasserIn]
• Titel: On the role of acylation of transmembrane proteins
• Verf.angabe: Diana Morozova and Matthias Weiss
• E-Jahr: 2010
• Jahr: 26 February 2010
• Umfang: 5 S.
• Fussnoten: Gesehen am 04.05.2023
• Titel Quelle: Enthalten in: Biophysical journal
• Ort Quelle: Cambridge, Mass. : Cell Press, 1960
• Jahr Quelle: 2010
• Band/Heft Quelle: 98(2010), 5, Seite 800-804
• ISSN Quelle: 1542-0086
• DOI: doi:10.1016/j.bpj.2009.11.014
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1844631559

Abstract

Acylation is a frequent means to ensure membrane association of a variety of soluble proteins in living cells. However, many transmembrane proteins are palmitoylated, indicating that this posttranslational modification may also serve as a means to regulate protein trafficking. Based on coarse-grained membrane simulations, we find that protein acylation significantly alters the tilting of transmembrane proteins with respect to the bilayer normal. In addition, the proteins' partitioning behavior and cluster formation ability due to hydrophobic mismatching is strongly altered. Based on our results, we propose that acylation is a potent means to regulate the trafficking of transmembrane proteins along the early secretory pathway.