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| Verfasst von: | Cloke, Thomas [VerfasserIn]  |
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| | Garvey, L. [VerfasserIn] |
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| | Choi, B.-S. [VerfasserIn] |
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| | Abebe, T. [VerfasserIn] |
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| | Hailu, A. [VerfasserIn] |
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| | Hancock, M. [VerfasserIn] |
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| | Kadolsky, U. [VerfasserIn] |
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| | Bangham, C. R. M. [VerfasserIn] |
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| | Munder, Markus [VerfasserIn] |
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| | Müller, I. [VerfasserIn] |
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| | Taylor, G. P. [VerfasserIn] |
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| | Kropf, P. [VerfasserIn] |
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| Titel: | Increased level of arginase activity correlates with disease severity in HIV-seropositive patients |
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| Verf.angabe: | T.E. Cloke, L. Garvey, B.-S. Choi, T. Abebe, A. Hailu, M. Hancock, U. Kadolsky, C.R.M. Bangham, M. Munder, I. Müller, G.P. Taylor, and P. Kropf |
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| E-Jahr: | 2010 |
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| Jahr: | 01 August 2010 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 05.05.2023 |
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| Titel Quelle: | Enthalten in: The journal of infectious diseases |
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| Ort Quelle: | Oxford [u.a.] : Oxford Univ. Press, 1904 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 202(2010), 3 vom: Aug., Seite 374-385 |
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| ISSN Quelle: | 1537-6613 |
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| Abstract: | Infection with human immunodeficiency virus (HIV) results in a chronic infection that progressively impairs the immune system. Although depletion of CD4(+) T cells is frequently used to explain immunosuppression, chronicity of infection and progressive loss of CD4(+) T cells are not sufficient to fully account for immune dysregulation. Arginase-induced l-arginine deprivation is emerging as a key mechanism for the down-regulation of immune responses. Here, we hypothesized that the level of arginase activity increases with disease severity in HIV-seropositive patients. We determined the levels of arginase activity in peripheral blood mononuclear cells from HIV-seropositive patients and uninfected control participants. Our results show that peripheral blood mononuclear cells from HIV-seropositive patients with low CD4(+) T cell counts expressed statistically significantly higher levels of arginase activity, compared with patients with high CD4(+) T cell counts or uninfected control participants. Furthermore, we found a statistically significant correlation between high level of arginase activity and high viral load in HIV-seropositive patients. |
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| DOI: | doi:10.1086/653736 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1086/653736 |
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| | DOI: https://doi.org/10.1086/653736 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Adult |
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| | Arginase |
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| | CD4 Lymphocyte Count |
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| | Cells, Cultured |
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| | Female |
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| | HIV |
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| | HIV Infections |
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| | Humans |
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| | Leukocytes, Mononuclear |
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| | Male |
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| | Middle Aged |
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| | Severity of Illness Index |
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| | Viral Load |
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| K10plus-PPN: | 1844710386 |
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| Verknüpfungen: | → Zeitschrift |
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Increased level of arginase activity correlates with disease severity in HIV-seropositive patients / Cloke, Thomas [VerfasserIn]; 01 August 2010 (Online-Ressource)
