Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis

• Verfasst von: Hirschberg, Alexandra [VerfasserIn]
• Verfasst von: Deng, Suhua [VerfasserIn]
• Verfasst von: Korostylev, Alexander [VerfasserIn]
• Verfasst von: Paldy, Eszter [VerfasserIn]
• Verfasst von: Costa, M. R. [VerfasserIn]
• Verfasst von: Worzfeld, Thomas [VerfasserIn]
• Verfasst von: Vodrazka, Peter [VerfasserIn]
• Verfasst von: Wizenmann, A. [VerfasserIn]
• Verfasst von: Götz, M. [VerfasserIn]
• Verfasst von: Offermanns, Stefan [VerfasserIn]
• Verfasst von: Kuner, Ruprecht [VerfasserIn]
• Titel: Gene Deletion Mutants Reveal a Role for Semaphorin Receptors of the Plexin-B Family in Mechanisms Underlying Corticogenesis
• Verf.angabe: A. Hirschberg, S. Deng, A. Korostylev, E. Paldy, M. R. Costa, T. Worzfeld, P. Vodrazka, A. Wizenmann, M. Götz, S. Offermanns, R. Kuner
• E-Jahr: 2010
• Jahr: [2010]
• Umfang: 17 S.
• Fussnoten: Published online: 20 Mar 2023 ; Elektronische Reproduktion der Druckausgabe ; Gesehen am 15.05.2023
• Titel Quelle: Enthalten in: Molecular and cellular biology
• Ort Quelle: Washington, DC : American Society for Microbiology, 1981
• Jahr Quelle: 2010
• Band/Heft Quelle: 30(2010), 3, Seite 764-780
• ISSN Quelle: 0270-7306
• DOI: doi:10.1128/MCB.01458-09
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1845389301

Abstract

Semaphorins and their receptors, plexins, are emerging as key regulators of various aspects of neural and nonneural development. Semaphorin 4D (Sema4D) and B-type plexins demonstrate distinct expression patterns over critical time windows during the development of the murine neocortex. Here, analysis of mice genetically lacking plexin-B1 or plexin-B2 revealed the significance of Sema4D-plexin-B signaling in cortical development. Deficiency of plexin-B2 resulted in abnormal cortical layering and defective migration and differentiation of several subtypes of cortical neurons, including Cajal-Retzius cells, GABAergic interneurons, and principal cells in vivo. In contrast, a lack of plexin-B1 did not impact on cortical development in vivo. In various ex vivo assays on embryonic forebrain, Sema4D enhanced the radial and tangential migration of developing neurons in a plexin-B2-dependent manner. These results suggest that Sema4D-plexin-B2 interactions regulate mechanisms underlying cell specification, differentiation, and migration during corticogenesis.