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| Verfasst von: | Grond-Ginsbach, Caspar [VerfasserIn]  |
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| | Pjontek, Rastislav [VerfasserIn] |
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| | Aksay, Suna Su [VerfasserIn] |
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| | Hyhlik-Dürr, Alexander [VerfasserIn] |
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| | Böckler, Dittmar [VerfasserIn] |
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| | Groß-Weissmann, Marie-Luise [VerfasserIn] |
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| Titel: | Spontaneous arterial dissection |
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| Titelzusatz: | phenotype and molecular pathogenesis |
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| Verf.angabe: | Caspar Grond-Ginsbach, Rastislav Pjontek, Suna Su Aksay, Alexander Hyhlik-Dürr, Dittmar Böckler, Marie-Luise Gross-Weissmann |
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| E-Jahr: | 2010 |
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| Jahr: | 14 February 2010 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 26.05.2023 |
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| Titel Quelle: | Enthalten in: Cellular and molecular life sciences |
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| Ort Quelle: | Cham (ZG) : Springer International Publishing AG, 1997 |
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| Jahr Quelle: | 2010 |
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| Band/Heft Quelle: | 67(2010), 11, Seite 1799-1815 |
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| ISSN Quelle: | 1420-9071 |
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| Abstract: | Arterial dissection (AD) is defined as the longitudinal splitting up of the arterial wall caused by intramural bleeding. It can occur as a spontaneous event in all large and medium sized arteries. The histological hallmark of AD is medial degeneration. Histological investigations, gene expression profiling and proteome studies of affected arteries reveal disturbances in many different biological processes including inflammation, proteolytic activity, cell proliferation, apoptosis and smooth muscle cell (SMC) contractile function. Medial degeneration can be caused by various rare dominant Mendelian disorders. Genetic linkage analysis lead to the identification of mutations in different disease-causing genes involved in the biosynthesis of the extracellular matrix (FBN1, COL3A1), in transforming growth factor (TGF) beta signaling (FBN1, TGFBR1, TGFBR2) and in the SMC contractile system (ACTA2, MYH11). Genome wide association studies suggest that the CDKN2A/CDKN2B locus plays a role in the etiology AD and other arterial diseases. |
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| DOI: | doi:10.1007/s00018-010-0276-z |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00018-010-0276-z |
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| | DOI: https://doi.org/10.1007/s00018-010-0276-z |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Aortic disease |
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| | Arterial dissection |
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| | Genetics |
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| | Matrix metalloproteinase (MMP) |
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| | Medial degeneration |
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| | Smooth muscle cell (SMC) |
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| | Transforming growth factor (TGF) beta signaling |
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| K10plus-PPN: | 184628242X |
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| Verknüpfungen: | → Zeitschrift |
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Spontaneous arterial dissection / Grond-Ginsbach, Caspar [VerfasserIn]; 14 February 2010 (Online-Ressource)
