| |  Online resource |
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| Verfasst von: | Ohara, Shinya [VerfasserIn]  |
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| | Rannap, Märt [VerfasserIn] |
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| | Tsutsui, Ken-Ichiro [VerfasserIn] |
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| | Draguhn, Andreas [VerfasserIn] |
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| | Egorov, Alexei [VerfasserIn] |
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| | Witter, Menno P. [VerfasserIn] |
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| Titel: | Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents |
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| Verf.angabe: | Shinya Ohara, Märt Rannap, Ken-Ichiro Tsutsui, Andreas Draguhn, Alexei V. Egorov, and Menno P. Witter |
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| E-Jahr: | 2023 |
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| Jahr: | 31 January 2023 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 09.06.2023 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 42(2023), 1 vom: Jan., Artikel-ID 112001, Seite 1-19 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dorsoventral organization of the hippocampal projection to the medial EC (MEC). While dorsal hippocampal projections are confined to the dorsal MEC, ventral hippocampal projections innervate both dorsal and ventral MEC. Further, whereas the dorsal hippocampus preferentially targets layer Vb (LVb) neurons, the ventral hippocampus mainly targets cells in layer Va (LVa). This connectivity scheme differs from hippocampal projections to the lateral EC, which are topographically organized along the dorsoventral axis. As LVa neurons project to telencephalic structures, our findings indicate that the ventral hippocampus regulates LVa-mediated entorhinal-neocortical output from both dorsal and ventral MEC. Overall, the marked dorsoventral differences in hippocampal-entorhinal connectivity impose important constraints on signal flow in hippocampal-neocortical circuits. |
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| DOI: | doi:10.1016/j.celrep.2023.112001 |
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| URL: | Bibliographic entry. University members only receive access to full-texts for open access or licensed publications.
kostenfrei: Volltext: https://doi.org/10.1016/j.celrep.2023.112001 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2211124723000128 |
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| | DOI: https://doi.org/10.1016/j.celrep.2023.112001 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | anterograde tracing |
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| | dorsoventral axis |
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| | electrophysiology |
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| | hippocampal area CA1 |
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| | hippocampal output circuit |
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| | lateral entorhinal cortex |
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| | layer V |
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| | medial entorhinal cortex |
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| | rodents |
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| | subiculum |
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| K10plus-PPN: | 1848551053 |
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| Verknüpfungen: | → Journal |
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Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents / Ohara, Shinya [VerfasserIn]; 31 January 2023 (Online-Ressource)
