Longitudinal magnetic resonance imaging detects onset and progression of chronic rhinosinusitis from infancy to school age in cystic fibrosis

• Verfasst von: Wucherpfennig, Lena [VerfasserIn]
• Verfasst von: Wünnemann, Felix [VerfasserIn]
• Verfasst von: Eichinger, Monika [VerfasserIn]
• Verfasst von: Schmitt, Niclas [VerfasserIn]
• Verfasst von: Seitz, Angelika [VerfasserIn]
• Verfasst von: Baumann, Ingo [VerfasserIn]
• Verfasst von: Stahl, Mirjam [VerfasserIn]
• Verfasst von: Graeber, Simon Y. [VerfasserIn]
• Verfasst von: Chung, Jaehi [VerfasserIn]
• Verfasst von: Schenk, Jens-Peter [VerfasserIn]
• Verfasst von: Alrajab, Abdulsattar [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Mall, Marcus A. [VerfasserIn]
• Verfasst von: Sommerburg, Olaf [VerfasserIn]
• Verfasst von: Wielpütz, Mark Oliver [VerfasserIn]
• Titel: Longitudinal magnetic resonance imaging detects onset and progression of chronic rhinosinusitis from infancy to school age in cystic fibrosis
• Verf.angabe: Lena Wucherpfennig, Felix Wuennemann, Monika Eichinger, Niclas Schmitt, Angelika Seitz, Ingo Baumann, Mirjam Stahl, Simon Y. Graeber, Jaehi Chung, Jens-Peter Schenk, Abdulsattar Alrajab, Hans-Ulrich Kauczor, Marcus A. Mall, Olaf Sommerburg, Mark O. Wielpütz
• Jahr: 2023
• Umfang: 11 S.
• Fussnoten: Gesehen am 20.06.2023
• Titel Quelle: Enthalten in: American Thoracic SocietyAnnals of the American Thoracic Society
• Ort Quelle: New York, NY : American Thoracic Society, 2013
• Jahr Quelle: 2023
• Band/Heft Quelle: 20(2023), 5, Seite 687-697
• ISSN Quelle: 2325-6621
• DOI: doi:10.1513/AnnalsATS.202209-763OC
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: airway disease
• Sach-SW: CF
• Sach-SW: chronic rhinosinusitis
• Sach-SW: MRI
• Sach-SW: mucus obstruction
• K10plus-PPN: 1850642834

Abstract

Rationale: Chronic rhinosinusitis (CRS) contributes to morbidity in patients with cystic fibrosis (CF). However, longitudinal data on CRS onset and progression is lacking. - - Objectives: To longitudinally evaluate CRS in CF from infancy to school age with paranasal sinus magnetic resonance imaging (MRI). - - Methods: A total of 64 children with CF (mean age at baseline, 1.1 ± 1.6 yr; range, 0-5 yr) underwent a mean of 5.8 ± 2.2 (range, 3-11 yr) subsequent annual MRI examinations. Additional 24 children (9.2 ± 4.4 yr; range, 3-17 yr) homozygous for the F508del mutation underwent MRI before and at least 2 months after starting lumacaftor/ivacaftor. MRI was assessed using the previously evaluated CRS-MRI score. - - Results: In infancy, 65-87% of paranasal sinuses were opacified, and mucosal swelling was the dominant abnormality (58-97%). At preschool age (1-5 yr), 79-94% of sinuses were opacified (P < 0.05 vs. infancy), and mucosal swelling was the most dominant abnormality (79-94%; P < 0.05). At school age (at least 6 yr), almost all sinuses were opacified (71-99%; P < 0.001-0.357 vs. preschool age), and mucopyoceles were the dominant abnormality in maxillary and frontal sinuses (53-56%; P < 0.05-0.808). The CRS-MRI sum score increased from 22.4 ± 9.6 in infancy to 34.2 ± 9.6 in preschool age (P < 0.001) and was 34.0 ± 5.7 in school age (P = 0.052). In children under lumacaftor/ivacaftor therapy, the CRS-MRI sum score (−0.5 ± 3.3; P < 0.05) and maxillary sinus subscore (−0.5 ± 1.5; P < 0.05) improved. - - Conclusions: Longitudinal paranasal sinus MRI detects an early onset and progression of the severity of CRS from infancy to school age, and response to lumacaftor/ivacaftor therapy in children with CF. Our data support its role in the comprehensive noninvasive monitoring of CRS in children with CF. - - Clinical trial registered with www.clinicaltrials.gov (NCT 02270476).