Enantioselective iridium-catalyzed allylic substitutions with hydroxamic acid derivatives as N-nucleophiles

• Verfasst von: Gärtner, Martin [VerfasserIn]
• Verfasst von: Jäkel, Mascha [VerfasserIn]
• Verfasst von: Achatz, Manuel [VerfasserIn]
• Verfasst von: Sonnenschein-Battefeld, Christoph [VerfasserIn]
• Verfasst von: Tverskoy, Olena [VerfasserIn]
• Verfasst von: Helmchen, Günter [VerfasserIn]
• Titel: Enantioselective iridium-catalyzed allylic substitutions with hydroxamic acid derivatives as N-nucleophiles
• Verf.angabe: Martin Gärtner, Mascha Jäkel, Manuel Achatz, Christoph Sonnenschein, Olena Tverskoy, and Günter Helmchen
• E-Jahr: 2011
• Jahr: 2 May 2011
• Umfang: 4 S.
• Fussnoten: Gesehen am 03.08.2023
• Titel Quelle: Enthalten in: Organic letters
• Ort Quelle: Washington, DC : ACS, 1999
• Jahr Quelle: 2011
• Band/Heft Quelle: 13(2011), 11 vom: Juni, Seite 2810-2813
• ISSN Quelle: 1523-7052
• DOI: doi:10.1021/ol200688d
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1854288938

Abstract

Enantioselective Ir-catalyzed allylic aminations with hydroxamic acid derivatives are described. Catalysts were prepared in situ from [Ir(cod)Cl]2 or [Ir(dbcot)Cl]2, a phosphoramidite and base. In addition, pure (π-allyl)Ir complexes containing cod or dbcot as auxiliary ligands were used. Very high degrees of regio- and enantioselectivity were achieved. The reaction products were transformed into piperidine derivatives suited as precursors for aza-sugars.