| |  Online-Ressource |
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| Verfasst von: | Stefanos-Yakoub, Ilona [VerfasserIn]  |
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| | Wingeier, Kevin [VerfasserIn] |
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| | Cserpan, Dorottya [VerfasserIn] |
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| | Gennari, Antonio Giulio [VerfasserIn] |
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| | Latal, Beatrice [VerfasserIn] |
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| | Reuner, Gitta [VerfasserIn] |
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| | Ramantani, Georgia [VerfasserIn] |
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| Titel: | Lesion extent negatively impacts intellectual skills in pediatric focal epilepsy |
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| Verf.angabe: | Ilona Stefanos-Yakoub, Kevin Wingeier, Dorottya Cserpan, Antonio Giulio Gennari, Beatrice Latal, Gitta Reuner, Georgia Ramantani |
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| E-Jahr: | 2023 |
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| Jahr: | August 2023 |
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| Umfang: | 7 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 17. Mai 2023, Artikelversion: 6. Juni 2023 ; Gesehen am 09.08.2023 |
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| Titel Quelle: | Enthalten in: Pediatric neurology |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1985 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 145(2023) vom: Aug., Seite 67-73 |
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| ISSN Quelle: | 1873-5150 |
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| Abstract: | Background - Cognitive development in children and adolescents with focal lesional epilepsy is determined by the underlying epileptogenic lesion, in addition to epilepsy itself. However, the impact of lesion-related variables on intelligence quotient (IQ) and developmental quotient (DQ) remains largely unexplored. Here, we aimed to determine the effect of lesion-related predictors and their relation with epilepsy-related predictors of intellectual functioning. - Methods - We retrospectively analyzed data from children with focal lesional epilepsy who underwent standardized cognitive evaluation yielding IQ/DQ in our institution. - Results - We included 50 consecutive patients aged 0.5 to 17.5 years (mean, 9.3; S.D., 4.9) at cognitive assessment. Epilepsy duration was 0 to 15.5 years (mean, 3.8; S.D., 4.1). Of the total cohort, 30 (60%) patients had unilobar lesions, seven (14%) multilobar, 10 (20%) hemispheric, and three (6%) bilateral. Etiology was congenital in 32 (64%) cases, acquired in 14 (28%), and progressive in four (8%). For patients with unilobar lesions, the mean IQ/DQ was 97.1 ± 15.7, for multilobar 98.9 ± 20.2, for hemispheric 76.1 ± 20.5, and for bilateral 76.3 ± 4.5. Larger lesion extent, earlier epilepsy onset, and longer epilepsy duration correlated with lower IQ/DQ in the univariate analysis, whereas only lesion extent and epilepsy duration contributed significantly to the explanatory model in the multivariable analysis. - Conclusions - The present study demonstrates that lesion extent and epilepsy duration are important risk factors for intellectual impairment in pediatric patients with focal lesional epilepsy. These findings are useful for family counseling and the early consideration of interventions that may limit the duration of epilepsy. |
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| DOI: | doi:10.1016/j.pediatrneurol.2023.05.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.pediatrneurol.2023.05.005 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S0887899423001480 |
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| | DOI: https://doi.org/10.1016/j.pediatrneurol.2023.05.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cognitive development |
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| | Intelligence |
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| | Lesion extent |
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| | Multilobar |
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| | Pediatric focal epilepsy |
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| K10plus-PPN: | 1854973118 |
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| Verknüpfungen: | → Zeitschrift |
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Lesion extent negatively impacts intellectual skills in pediatric focal epilepsy / Stefanos-Yakoub, Ilona [VerfasserIn]; August 2023 (Online-Ressource)
