Progression and associated factors of lacquer cracks/patchy atrophies in high myopia

• Verfasst von: Jonas, Jost B. [VerfasserIn]
• Verfasst von: Xu, Liang [VerfasserIn]
• Verfasst von: Wei, Wen Bin [VerfasserIn]
• Verfasst von: Jonas, Rahul A. [VerfasserIn]
• Verfasst von: Wang, Ya Xing [VerfasserIn]
• Titel: Progression and associated factors of lacquer cracks/patchy atrophies in high myopia
• Titelzusatz: the Beijing Eye Study 2001-2011 : retinal disorders
• Verf.angabe: Jost B. Jonas, Liang Xu, Wen Bin Wei, Rahul A. Jonas, Ya Xing Wang
• E-Jahr: 2022
• Jahr: 24 May 2022
• Umfang: 9 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 14.08.2023
• Titel Quelle: Enthalten in: Graefe's archive for clinical and experimental ophthalmology
• Ort Quelle: Berlin : Springer, 1854
• Jahr Quelle: 2022
• Band/Heft Quelle: 260(2022), 10 vom: Okt., Seite 3221-3229
• ISSN Quelle: 1435-702X
• DOI: doi:10.1007/s00417-022-05705-7
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: High myopia
• Sach-SW: Lacquer crack
• Sach-SW: Myopic maculopathy
• Sach-SW: Optic disc
• Sach-SW: Optic nerve head
• Sach-SW: Parapapillary delta zone
• Sach-SW: Parapapillary gamma zone
• Sach-SW: Patchy atrophy
• K10plus-PPN: 1856089630
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Purpose: To assess the development and progression of lacquer cracks/patchy atrophies (LCs/PAs) in high myopia. Methods: The case control study included highly myopic eyes (refractive error ≤  − 6.0 diopters), examined in the population-based Beijing Eye Study 2001/2011. Using fundus photographs taken in 2001 and 2011 and optical coherence tomographic images obtained in 2011, we assessed the incidence and enlargement of pre-existing LC/PAs. Results: The study included 89 highly myopic eyes (age: 65.0 ± 9.4 years). Newly developed or enlarged LC/PAs were detected in 17 (19.1%; 95% confidence interval (CI): 11.0, 27.0) eyes, with a new LC development without previous LCs, enlargement of a pre-existing LC, LC enlargement to a PA, development of a new PA without any previous LCs, and enlargement of a pre-existing PA detected in 3, 3, 5, 3, and 3 eyes, respectively. In 14 (82.4%; 95%CI: 62.3, 100) of the 17 eyes with LC/PA development or enlargement, the LC/PAs elongated perpendicularly to, and widened in, the direction of gamma zone enlargement. Higher prevalence of LC/PA enlargement was associated (multivariable analysis) with higher myopic maculopathy stage in 2001 (odds ratio (OR): 7.83; 95%CI: 2.65, 23.2; P < 0.001) and higher frequency of parapapillary delta zone enlargement (OR: 32.0; 95%CI: 3.07, 334; P < 0.001). Prevalence of LC/PA enlargement was lower than the prevalence of changes in other myopic maculopathy features (disc-fovea distance elongation: 71%; choroidal vessel shift: 55%; reduction in ophthalmoscopical disc size: 34%; ophthalmoscopic disc size enlargement: 25%). All eyes with LC/PA enlargement showed a pre-existing and enlarging gamma zone. Conclusions: Development and enlargement of LC/PAs were associated with enlargement of parapapillary delta zone and often occurred in association with the direction of gamma zone enlargement.