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| Verfasst von: | Papaioannou, Sophia [VerfasserIn]  |
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| | See, Jia-Xiang [VerfasserIn] |
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| | Jeong, Mingeum [VerfasserIn] |
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| | Torre, Carolina de la [VerfasserIn] |
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| | Ast, Volker [VerfasserIn] |
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| | Reiners-Koch, Philipp-Sebastian [VerfasserIn] |
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| | Sati, Ankita [VerfasserIn] |
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| | Mogler, Carolin [VerfasserIn] |
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| | Platten, Michael [VerfasserIn] |
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| | Cerwenka, Adelheid [VerfasserIn] |
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| | Stojanovic, Ana [VerfasserIn] |
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| Titel: | Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury |
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| Verf.angabe: | Sophia Papaioannou, Jia-Xiang See, Mingeum Jeong, Carolina De La Torre, Volker Ast, Philipp-Sebastian Reiners-Koch, Ankita Sati, Carolin Mogler, Michael Platten, Adelheid Cerwenka, and Ana Stojanovic |
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| E-Jahr: | 2023 |
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| Jahr: | 29 August 2023 |
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| Umfang: | 19 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online verfügbar: 19. Juli 2023 ; Gesehen am 05.10.2023 |
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| Titel Quelle: | Enthalten in: Cell reports |
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| Ort Quelle: | Maryland Heights, MO : Cell Press, 2012 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 42(2023), 8 vom: Aug., Artikel-ID 112836, Seite 1-19 |
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| ISSN Quelle: | 2211-1247 |
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| Abstract: | Liver sinusoidal endothelial cells (LSECs) rapidly clear lipopolysaccharide (LPS) from the bloodstream and establish intimate contact with immune cells. However, their role in regulating liver inflammation remains poorly understood. We show that LSECs modify their chemokine expression profile driven by LPS or interferon-γ (IFN-γ), resulting in the production of the myeloid- or lymphoid-attracting chemokines CCL2 and CXCL10, respectively, which accumulate in the serum of LPS-challenged animals. Natural killer (NK) cell exposure to LSECs in vitro primes NK cells for higher production of IFN-γ in response to interleukin-12 (IL-12) and IL-18. In livers of LPS-injected mice, NK cells are the major producers of this cytokine. In turn, LSECs require exposure to IFN-γ for CXCL10 expression, and endothelial-specific Cxcl10 gene deletion curtails NK cell accumulation in the inflamed livers. Thus, LSECs respond to both LPS and immune-derived signals and fuel a positive feedback loop of immune cell attraction and activation in the inflamed liver tissue. |
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| DOI: | doi:10.1016/j.celrep.2023.112836 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1016/j.celrep.2023.112836 |
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| | kostenfrei: Volltext: https://www.sciencedirect.com/science/article/pii/S2211124723008471 |
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| | DOI: https://doi.org/10.1016/j.celrep.2023.112836 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CXCL10 |
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| | IFN-γ |
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| | liver endothelial cells |
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| | liver inflammation |
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| | LPS |
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| | LSECs |
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| | NK cell migration |
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| | NK cells |
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| K10plus-PPN: | 1860750524 |
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| Verknüpfungen: | → Zeitschrift |
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Liver sinusoidal endothelial cells orchestrate NK cell recruitment and activation in acute inflammatory liver injury / Papaioannou, Sophia [VerfasserIn]; 29 August 2023 (Online-Ressource)
