| |  Online-Ressource |
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| Verfasst von: | Dai, Rongjie [VerfasserIn]  |
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| | Herold, Christina [VerfasserIn] |
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| | Wang, Xingsong [VerfasserIn] |
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| | Kong, Li [VerfasserIn] |
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| | Schröder, Johannes [VerfasserIn] |
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| Titel: | Structural brain networks in schizophrenia based on nonnegative matrix factorization |
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| Verf.angabe: | Rongjie Dai, Christina J. Herold, Xingsong Wang, Li Kong, Johannes Schröder |
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| E-Jahr: | 2023 |
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| Jahr: | 20 July 2023 |
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| Umfang: | 7 S. |
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| Fussnoten: | Gesehen am 05.10.2023 |
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| Titel Quelle: | Enthalten in: Psychiatry research. Neuroimaging |
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| Ort Quelle: | Amsterdam : Elsevier, 1990 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 334(2023), Artikel-ID 111690, Seite 1-7 |
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| ISSN Quelle: | 1872-7506 |
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| Abstract: | Schizophrenia is a severe mental disease with significant morphometric reductions in gray matter volume and cortical thickness in a variety of brain regions. However, most studies only focused on the voxel level alterations in specific cerebral regions and ignored the spatial relationship between voxels. In the present study, we used a novel, data-driven technique-nonnegative matrix factorization (NMF) to group voxels with similar information into a network, and studied the structural covariance at the network level in schizophrenia. Our sample included 36 patients with schizophrenia and 21 healthy controls. Compared with healthy controls, patients with schizophrenia showed significant gray matter volume reductions in six structural covariance networks (dorsal striatum, thalamus, hippocampus-parahippocampus, supplementary motor area-fusiform, middle/inferior temporal network, frontal-parietal-occipital network). Our findings confirmed the assumption of a disturbance in the cortical-subcortical circuit in schizophrenia and suggested that NMF is a useful multivariate method to identify brain networks, which provides a new perspective to study the neural mechanism in schizophrenia. |
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| DOI: | doi:10.1016/j.pscychresns.2023.111690 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.pscychresns.2023.111690 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S0925492723001002 |
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| | DOI: https://doi.org/10.1016/j.pscychresns.2023.111690 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Nonnegative matrix factorization |
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| | Schizophrenia |
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| | Structural network |
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| K10plus-PPN: | 1860775292 |
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| Verknüpfungen: | → Zeitschrift |
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Structural brain networks in schizophrenia based on nonnegative matrix factorization / Dai, Rongjie [VerfasserIn]; 20 July 2023 (Online-Ressource)
