Fast kilovoltage/megavoltage (kVMV) breathhold cone-beam CT for image-guided radiotherapy of lung cancer

• Verfasst von: Wertz, Hansjörg [VerfasserIn]
• Verfasst von: Stsepankou, Dzmitry [VerfasserIn]
• Verfasst von: Blessing, Manuel [VerfasserIn]
• Verfasst von: Rossi, Michael [VerfasserIn]
• Verfasst von: Knox, Chris [VerfasserIn]
• Verfasst von: Brown, Kevin [VerfasserIn]
• Verfasst von: Gros, Uwe [VerfasserIn]
• Verfasst von: Boda-Heggemann, Judit [VerfasserIn]
• Verfasst von: Walter, Cornelia [VerfasserIn]
• Verfasst von: Hesser, Jürgen [VerfasserIn]
• Verfasst von: Lohr, Frank [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Titel: Fast kilovoltage/megavoltage (kVMV) breathhold cone-beam CT for image-guided radiotherapy of lung cancer
• Verf.angabe: Hansjoerg Wertz, Dzmitry Stsepankou, Manuel Blessing, Michael Rossi, Chris Knox, Kevin Brown, Uwe Gros, Judit Boda-Heggemann, Cornelia Walter, Juergen Hesser, Frank Lohr and Frederik Wenz
• E-Jahr: 2010
• Jahr: 8 July 2010
• Umfang: 15 S.
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 29.11.2023
• Titel Quelle: Enthalten in: Physics in medicine and biology
• Ort Quelle: Bristol : IOP Publ., 1956
• Jahr Quelle: 2010
• Band/Heft Quelle: 55(2010), 15, Seite 4203-4217
• ISSN Quelle: 1361-6560
• DOI: doi:10.1088/0031-9155/55/15/001
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1871582822

Abstract

Long image acquisition times of 60-120 s for cone-beam CT (CBCT) limit the number of patients with lung cancer who can undergo volume image guidance under breathhold. We developed a low-dose dual-energy kilovoltage-megavoltage-cone-beam CT (kVMV-CBCT) based on a clinical treatment unit reducing imaging time to ⩽15 s. Simultaneous kVMV-imaging was achieved by dedicated synchronization hardware controlling the output of the linear accelerator (linac) based on detector panel readout signals, preventing imaging artifacts from interference of the linac's MV-irradiation and panel readouts. Optimization was performed to minimize the imaging dose. Single MV-projections, reconstructed MV-CBCT images and images of simultaneous 90° kV- and 90° MV-CBCT (180° kVMV-CBCT) were acquired with different parameters. Image quality and imaging dose were evaluated and compared to kV-imaging. Hardware-based kVMV synchronization resulted in artifact-free projections. A combined 180° kVMV-CBCT scan with a total MV-dose of 5 monitor units was acquired in 15 s and with sufficient image quality. The resolution was 5-6 line pairs cm−1 (Catphan phantom). The combined kVMV-scan dose was equivalent to a kV-radiation scan dose of ∼33 mGy. kVMV-CBCT based on a standard linac is promising and can provide ultra-fast online volume image guidance with low imaging dose and sufficient image quality for fast and accurate patient positioning for patients with lung cancer under breathhold.