| |  Online-Ressource |
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| Verfasst von: | Chakraborty, Sushmita [VerfasserIn]  |
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| | Gupta, Ranjan [VerfasserIn] |
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| | Hieke-Kubatzky, Katharina [VerfasserIn] |
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| | Kar, Santanu [VerfasserIn] |
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| | Kraus, Franziska V. [VerfasserIn] |
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| | Souto-Carneiro, Maria Margarida [VerfasserIn] |
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| | Lorenz, Hanns-Martin [VerfasserIn] |
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| | Kumar, Pankaj [VerfasserIn] |
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| | Kumar, Vijay [VerfasserIn] |
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| | Mitra, Dipendra Kumar [VerfasserIn] |
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| Titel: | Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis |
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| Verf.angabe: | Sushmita Chakraborty, Ranjan Gupta, Katharina F. Kubatzky, Santanu Kar, Franziska V. Kraus, M. Margarida Souto-Carneiro, Hanns-Martin Lorenz, Pankaj Kumar, Vijay Kumar, Dipendra Kumar Mitra |
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| E-Jahr: | 2023 |
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| Jahr: | December 2023 |
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| Umfang: | 13 S. |
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| Fussnoten: | Online verfügbar 23 October 2023, Version des Artikels 29 October 2023 ; Gesehen am 15.01.2024 |
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| Titel Quelle: | Enthalten in: Clinical immunology |
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| Ort Quelle: | San Diego, Calif. : Elsevier, 1999 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 257(2023) vom: Dez., Artikel-ID 109814, Seite 1-13 |
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| ISSN Quelle: | 1521-7035 |
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| Abstract: | In Rheumatoid Arthritis (RA), regulatory T cells (Tregs) have been found to be enriched in the synovial fluid. Despite their accumulation, they are unable to suppress synovial inflammation. Recently, we showed the synovial enrichment of interleukin-9 (IL-9) producing helper T cells and its positive correlation with disease activity. Therefore, we investigated the impact of IL-9 on synovial Tregs in RA. Here, we confirmed high synovial Tregs in RA patients, however these cells were functionally impaired in terms of suppressive cytokine production (IL-10 and TGF-β). Abrogating IL-9/ IL-9 receptor interaction could restore the suppressive cytokine production of synovial Tregs and reduce the synovial inflammatory T cells producing IFN-γ, TNF-α, IL-17. However, blocking these inflammatory cytokines failed to show any effect on IL-9 producing T cells, highlighting IL-9's hierarchy in the inflammatory network. Thus, we propose that blocking IL-9 might dampen synovial inflammation by restoring Tregs function and inhibiting inflammatory T cells. |
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| DOI: | doi:10.1016/j.clim.2023.109814 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.clim.2023.109814 |
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| | Volltext: https://www.sciencedirect.com/science/article/pii/S1521661623005776 |
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| | DOI: https://doi.org/10.1016/j.clim.2023.109814 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Inflammatory cytokines |
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| | Interleukin −9 |
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| | Regulatory T cells |
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| | Rheumatoid arthritis |
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| | Synovial fluid |
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| K10plus-PPN: | 1878046802 |
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| Verknüpfungen: | → Zeitschrift |
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Negative impact of Interleukin-9 on synovial regulatory T cells in rheumatoid arthritis / Chakraborty, Sushmita [VerfasserIn]; December 2023 (Online-Ressource)
