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| Verfasst von: | Li, Lin [VerfasserIn]  |
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| | Zou, Yuting [VerfasserIn] |
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| | Liu, Baoe [VerfasserIn] |
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| | Yang, Runan [VerfasserIn] |
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| | Yang, Jingjian [VerfasserIn] |
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| | Sun, Minghao [VerfasserIn] |
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| | Li, Zijing [VerfasserIn] |
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| | Xu, Xiumei [VerfasserIn] |
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| | Li, Guilin [VerfasserIn] |
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| | Liu, Shuangmei [VerfasserIn] |
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| | Greffrath, Wolfgang [VerfasserIn] |
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| | Treede, Rolf-Detlef [VerfasserIn] |
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| | Li, Guodong [VerfasserIn] |
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| | Liang, Shangdong [VerfasserIn] |
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| Titel: | Contribution of the P2X4 receptor in rat Hippocampus to the comorbidity of chronic pain and depression |
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| Verf.angabe: | Lin Li, Yuting Zou, Baoe Liu, Runan Yang, Jingjian Yang, Minghao Sun, Zijing Li, Xiumei Xu, Guilin Li, Shuangmei Liu, Wolfgang Greffrath, Rolf-Detlef Treede, Guodong Li, and Shangdong Liang |
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| E-Jahr: | 2020 |
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| Jahr: | December 7, 2020 |
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| Umfang: | 11 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 23.01.2024 |
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| Titel Quelle: | Enthalten in: American Chemical SocietyACS chemical neuroscience |
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| Ort Quelle: | Washington, DC : ACS Publ., 2010 |
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| Jahr Quelle: | 2020 |
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| Band/Heft Quelle: | 11(2020), 24 vom: Dez., Seite 4387-4397 |
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| ISSN Quelle: | 1948-7193 |
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| Abstract: | The hippocampus is an important region for the interaction between depression and pain. Studies show that the P2X4 receptor plays key role in neuropathic pain. This work investigated the potential implication of the P2X4 receptor in the hippocampus in comorbidity of chronic pain and depression. The rat model induced by chronic constriction injury (CCI) plus unpredictable chronic mild stress (UCMS) was used in this study. Our data showed that CCI plus UCMS treatment resulted in abnormal changes in pain and depressive-like behaviors in the rat, accompanied by the upregulated expression of P2X4, NLRP3 (NOD-like receptor protein 3) inflammasome, and interleukin-1β and the activation of p38 MAPK in the hippocampus. The P2X4 antagonist 5-BDBD reversed these abnormal changes in the hippocampus, relieved hippocampal neuronal damage, and alleviated the abnormal pain and depressive-like behaviors in the CCI plus UCMS treated rats. These findings suggest that the P2X4 receptor in the hippocampus may mediate and significantly contribute to the pathological processes of comorbid pain and depression. |
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| DOI: | doi:10.1021/acschemneuro.0c00623 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1021/acschemneuro.0c00623 |
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| | Volltext: https://pubs.acs.org/doi/10.1021/acschemneuro.0c00623# |
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| | DOI: https://doi.org/10.1021/acschemneuro.0c00623 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1878775928 |
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| Verknüpfungen: | → Zeitschrift |
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Contribution of the P2X4 receptor in rat Hippocampus to the comorbidity of chronic pain and depression / Li, Lin [VerfasserIn]; December 7, 2020 (Online-Ressource)
