The effect of cytokine adsorption on leukocyte and platelet activation after extracorporeal cardiopulmonary resuscitation

• Verfasst von: Zahn, Timm [VerfasserIn]
• Verfasst von: Schanze, Nancy [VerfasserIn]
• Verfasst von: Staudacher, Dawid L. [VerfasserIn]
• Verfasst von: Wengenmayer, Tobias [VerfasserIn]
• Verfasst von: Maier, Sven [VerfasserIn]
• Verfasst von: Benk, Christoph [VerfasserIn]
• Verfasst von: Gauchel, Nadine [VerfasserIn]
• Verfasst von: Dürschmied, Daniel [VerfasserIn]
• Verfasst von: Supady, Alexander [VerfasserIn]
• Titel: The effect of cytokine adsorption on leukocyte and platelet activation after extracorporeal cardiopulmonary resuscitation
• Verf.angabe: Timm Zahn, Nancy Schanze, Dawid L. Staudacher, Tobias Wengenmayer, Sven Maier, Christoph Benk, Nadine Gauchel, Daniel Duerschmied, Alexander Supady
• E-Jahr: 2024
• Jahr: 10. Januar 2024
• Umfang: ?
• Illustrationen: Illustrationen
• Fussnoten: Gesehen am 26.02.2024
• Titel Quelle: Enthalten in: Thrombosis and haemostasis
• Ort Quelle: Stuttgart : Thieme, 1976
• Jahr Quelle: 2024
• Band/Heft Quelle: (2024), online ahead of print
• ISSN Quelle: 2567-689X
• DOI: doi:10.1055/a-2225-5173
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1881569098

Abstract

Background: Post-cardiac arrest syndrome (PCAS) is a frequent complication following successful cardiopulmonary resuscitation and correlates with poor outcome. PCAS is characterized by an excessive inflammatory response to whole-body ischemia and reperfusion. Cytokine adsorption was suggested as an adjunctive treatment option for the removal of cytokines from the patients' blood to restore the physiological equilibrium of pro- and anti-inflammatory activity and thus mitigate hemodynamic instability and end-organ complications. Material and Methods: To better understand the cellular effects of cytokine adsorption in patients receiving extracorporeal cardiopulmonary resuscitation (ECPR) after in- and out-of-hospital cardiac arrest, we compared the activation status of neutrophils, monocytes, and platelets as well as the formation of platelet-leukocyte complexes in intravenous whole blood samples from an exploratory subgroup (n = 24) from the randomized CYTER study. Result: At 48 hours after initiation of ECPR, flow cytometry analyses did neither reveal significant differences in neutrophil (CD11b, CD66b, L-selectin, and PSGL-1) and monocyte (CD11b, L-selectin, and PSGL-1) surface molecule expression nor in circulating platelet-monocyte complexes between patients receiving cytokine adsorption and those without. Conclusion: Data did not show a relevant effect of cytokine adsorption on neutrophil and monocyte activation during the first 48 hours after initiation of ECPR.