Schwann cells in neuromuscular in vitro models

• Verfasst von: Hörner, Sarah J. [VerfasserIn]
• Verfasst von: Couturier, Nathalie [VerfasserIn]
• Verfasst von: Hafner, Mathias [VerfasserIn]
• Verfasst von: Rudolf, Rüdiger [VerfasserIn]
• Titel: Schwann cells in neuromuscular in vitro models
• Verf.angabe: Sarah Janice Hörner, Nathalie Couturier, Mathias Hafner und Rüdiger Rudolf
• E-Jahr: 2024
• Jahr: 2024-01-29
• Umfang: 6 S.
• Fussnoten: Online veröffentlicht: 27. Juni 2023 ; Gesehen am 26.02.2024
• Titel Quelle: Enthalten in: Biological chemistry
• Ort Quelle: Berlin [u.a.] : de Gruyter, 1996
• Jahr Quelle: 2024
• Band/Heft Quelle: 405(2024), 1 vom: Jan., Seite 25-30
• ISSN Quelle: 1437-4315
• DOI: doi:10.1515/hsz-2023-0172
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: glia
• Sach-SW: neuromuscular junction
• Sach-SW: NMJ
• Sach-SW: stem cells
• Sach-SW: tissue engineering
• K10plus-PPN: 1881570851

Abstract

Neuromuscular cell culture models are used to investigate synapse formation and function, as well as mechanisms of de-and regeneration in neuromuscular diseases. Recent developments including 3D culture technique and hiPSC technology have propelled their ability to complement insights from in vivo models. However, most cultures have not considered Schwann cells, the glial part of NMJs. In the following, a brief overview of different types of neuromuscular cocultures is provided alongside examples for studies that included Schwann cells. From these, findings concerning the effects of Schwann cells on those cultures are summarized and future lines of research are proposed.