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| Verfasst von: | Holz, Nathalie E. [VerfasserIn]  |
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| | Zabihi, Mariam [VerfasserIn] |
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| | Kia, Seyed Mostafa [VerfasserIn] |
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| | Monninger, Maximillian [VerfasserIn] |
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| | Aggensteiner, Pascal [VerfasserIn] |
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| | Siehl, Sebastian [VerfasserIn] |
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| | Floris, Dorothea L. [VerfasserIn] |
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| | Bokde, Arun L. W. [VerfasserIn] |
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| | Desrivières, Sylvane [VerfasserIn] |
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| | Flor, Herta [VerfasserIn] |
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| | Grigis, Antoine [VerfasserIn] |
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| | Garavan, Hugh [VerfasserIn] |
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| | Gowland, Penny [VerfasserIn] |
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| | Heinz, Andreas [VerfasserIn] |
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| | Brühl, Rüdiger [VerfasserIn] |
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| | Martinot, Jean-Luc [VerfasserIn] |
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| | Martinot, Marie-Laure Paillère [VerfasserIn] |
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| | Orfanos, Dimitri Papadopoulos [VerfasserIn] |
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| | Paus, Tomáš [VerfasserIn] |
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| | Poustka, Luise [VerfasserIn] |
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| | Fröhner, Juliane [VerfasserIn] |
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| | Smolka, Michael [VerfasserIn] |
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| | Vaidya, Nilakshi [VerfasserIn] |
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| | Walter, Henrik [VerfasserIn] |
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| | Whelan, Robert [VerfasserIn] |
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| | Schumann, Gunter [VerfasserIn] |
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| | Meyer-Lindenberg, Andreas [VerfasserIn] |
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| | Brandeis, Daniel [VerfasserIn] |
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| | Buitelaar, Jan K. [VerfasserIn] |
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| | Nees, Frauke [VerfasserIn] |
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| | Beckmann, Christian [VerfasserIn] |
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| | Banaschewski, Tobias [VerfasserIn] |
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| | Marquand, Andre F. [VerfasserIn] |
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| Titel: | A stable and replicable neural signature of lifespan adversity in the adult brain |
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| Verf.angabe: | Nathalie E. Holz, Mariam Zabihi, Seyed Mostafa Kia, Maximillian Monninger, Pascal-M. Aggensteiner, Sebastian Siehl, Dorothea L. Floris, Arun L.W. Bokde, Sylvane Desrivières, Herta Flor, Antoine Grigis, Hugh Garavan, Penny Gowland, Andreas Heinz, Rüdiger Brühl, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Juliane H. Fröhner, Michael N. Smolka, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Andreas Meyer-Lindenberg, Daniel Brandeis, Jan K. Buitelaar, Frauke Nees, Christian Beckmann, Tobias Banaschewski & Andre F. Marquand |
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| E-Jahr: | 2023 |
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| Jahr: | September 2023 |
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| Umfang: | 29 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 21. August 2023 ; Gesehen am 11.09.2024 |
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| Titel Quelle: | Enthalten in: Nature neuroscience |
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| Ort Quelle: | New York, NY : Nature America, 1998 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 26(2023), 9, Seite 1603-1612[1-19] |
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| ISSN Quelle: | 1546-1726 |
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| Abstract: | Environmental adversities constitute potent risk factors for psychiatric disorders. Evidence suggests the brain adapts to adversity, possibly in an adversity-type and region-specific manner. However, the long-term effects of adversity on brain structure and the association of individual neurobiological heterogeneity with behavior have yet to be elucidated. Here we estimated normative models of structural brain development based on a lifespan adversity profile in a longitudinal at-risk cohort aged 25 years (n = 169). This revealed widespread morphometric changes in the brain, with partially adversity-specific features. This pattern was replicated at the age of 33 years (n = 114) and in an independent sample at 22 years (n = 115). At the individual level, greater volume contractions relative to the model were predictive of future anxiety. We show a stable neurobiological signature of adversity that persists into adulthood and emphasize the importance of considering individual-level rather than group-level predictions to explain emerging psychopathology. |
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| DOI: | doi:10.1038/s41593-023-01410-8 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.1038/s41593-023-01410-8 |
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| | kostenfrei: Volltext: https://www.nature.com/articles/s41593-023-01410-8 |
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| | DOI: https://doi.org/10.1038/s41593-023-01410-8 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Predictive markers |
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| | Stress and resilience |
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| K10plus-PPN: | 1902357140 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ stable and replicable neural signature of lifespan adversity in the adult brain / Holz, Nathalie E. [VerfasserIn]; September 2023 (Online-Ressource)
