Active gel model for one-dimensional cell migration coupling actin flow and adhesion dynamics

• Verfasst von: Wössner, Valentin [VerfasserIn]
• Verfasst von: Drozdowski, Oliver [VerfasserIn]
• Verfasst von: Ziebert, Falko [VerfasserIn]
• Verfasst von: Schwarz, Ulrich S. [VerfasserIn]
• Titel: Active gel model for one-dimensional cell migration coupling actin flow and adhesion dynamics
• Verf.angabe: Valentin Wössner, Oliver M Drozdowski, Falko Ziebert and Ulrich S Schwarz
• E-Jahr: 2024
• Jahr: 25 July 2024
• Umfang: 17 S.
• Fussnoten: Gesehen am 02.12.2024
• Titel Quelle: Enthalten in: New journal of physics
• Ort Quelle: [Bad Honnef] : Dt. Physikalische Ges., 1999
• Jahr Quelle: 2024
• Band/Heft Quelle: 26(2024), 7, Artikel-ID 073039, Seite 1-17
• ISSN Quelle: 1367-2630
• DOI: doi:10.1088/1367-2630/ad63c5
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 191057712X

Abstract

Abstract - Migration of animal cells is based on the interplay between actin polymerization at the front, adhesion along the cell-substrate interface, and actomyosin contractility at the back. Active gel theory has been used before to demonstrate that actomyosin contractility is sufficient for polarization and self-sustained cell migration in the absence of external cues, but did not consider the dynamics of adhesion. Likewise, migration models based on the mechanosensitive dynamics of adhesion receptors usually do not include the global dynamics of intracellular flow. Here we show that both aspects can be combined in a minimal active gel model for one-dimensional cell migration with dynamic adhesion. This model demonstrates that load sharing between the adhesion receptors leads to symmetry breaking, with stronger adhesion at the front, and that bistability of migration arises for intermediate adhesiveness. Local variations in adhesiveness are sufficient to switch between sessile and motile states, in qualitative agreement with experiments.